1414524-11-0Relevant articles and documents
Synthesis and evaluation of apoptosis induction of thienopyrimidine compounds on KRAS and BRAF mutated colorectal cancer cell lines
Pedeboscq, Stephane,Pometan, Jean-Paul,Gravier, Denis,Casadebaig, Francoise,Hou, Genevieve,Gissot, Arnaud,Rey, Christophe,Ichas, Francois,Giorgi, Francesca De,Lartigue, Lydia
, p. 6724 - 6731,8 (2012/12/12)
Monoclonal antibodies (MoAb) and tyrosine kinase inhibitors (TKI) targeting the EGFR (Epidermal Growth Factor Receptor) pathways are currently used in colorectal cancer treatment. Despite the improvement of median overall survival, resistance is observed