1414859-66-7

Basic information

• Product Name: (R)-N-benzyl-2-hydroxy-4-phenylbutanamide
• Synonyms: (R)-N-benzyl-2-hydroxy-4-phenylbutanamide
• CAS NO: 1414859-66-7
• Molecular Weight: 269.343
• Mol File: 1414859-66-7.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: (R)-N-benzyl-2-hydroxy-4-phenylbutanamide(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-N-benzyl-2-hydroxy-4-phenylbutanamide(1414859-66-7)
• EPA Substance Registry System: (R)-N-benzyl-2-hydroxy-4-phenylbutanamide(1414859-66-7)

Safety Data

• Hazardous Substances Data: 1414859-66-7(Hazardous Substances Data)

Upstream product

• 117-34-0 2,2-diphenylacetic acid 
• 134970-53-9 N-benzyl-2-hydroxy-4-phenylbutanamide 
• 29678-81-7 (R)-2-hydroxy4-phenylbutanoic acid 
• 100-46-9 benzylamine 
• 64920-29-2 2-oxo-4-phenylbutanoic acid ethyl ester 

Relevant articles and documents

Kinetic resolution of racemic 2-hydroxyamides using a diphenylacetyl component as an acyl source and a chiral acyl-transfer catalyst

Various optically active 2-hydroxyamide derivatives are produced based on the kinetic resolution of racemic 2-hydroxyamides with a diphenylacetyl component and (R)-benzotetramisole ((R)-BTM), a chiral acyl-transfer catalyst, via asymmetric esterification and acylation. It was revealed that a tertiary amide can be used with this novel protocol to achieve high selectivity (22 examples; s-value reaching over 250). The resulting chiral compounds could be transformed into other useful structures while maintaining their chirality.

Biocatalytic reduction of α-keto amides to (R)-α-hydroxy amides using Candida parapsilosis ATCC 7330

Biocatalytic reduction of primary and secondary α-keto amides was accomplished using whole cells of Candida parapsilosis ATCC 7330. The primary (R)-α-hydroxy amides were obtained in good enantiomeric excess (up to 94%) and conversion (88-99%) as compared to the secondary (R)-α-hydroxy amides.