1414976-16-1

Basic information

• Product Name: 4-((7-methyl-1H-indazol-5-yl)methylene)-2-phenyloxazol-5(4H)-one
• Synonyms: 4-((7-methyl-1H-indazol-5-yl)methylene)-2-phenyloxazol-5(4H)-one
• CAS NO: 1414976-16-1
• Molecular Weight: 303.32
• Mol File: 1414976-16-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4-((7-methyl-1H-indazol-5-yl)methylene)-2-phenyloxazol-5(4H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 4-((7-methyl-1H-indazol-5-yl)methylene)-2-phenyloxazol-5(4H)-one(1414976-16-1)
• EPA Substance Registry System: 4-((7-methyl-1H-indazol-5-yl)methylene)-2-phenyloxazol-5(4H)-one(1414976-16-1)

Safety Data

• Hazardous Substances Data: 1414976-16-1(Hazardous Substances Data)

Upstream product

• 635712-40-2 7-methyl-1H-indazole-5-carbaldehyde 
• 495-69-2 Hippuric Acid 
• 156454-43-2 5-bromo-7-methyl-1H-indazole 
• 24596-19-8 4-bromo-2,6-dimethylphenylamine 

Downstream Products

• 1414976-17-2 methyl 2-benzamido-3-(7-methyl-1H-indazol-5-yl)-acrylate 

Relevant articles and documents

Selection of an enantioselective process for the preparation of a CGRP receptor inhibitor

(R)-N-(3-(7-Methyl-1H-indazol-5-yl)-1-(4-(1-methylpiperidin-4-yl) piperazine-1-yl)-1-oxopropan-2-yl)-4-(2-oxo-1,2-dihydroquinolin-3-yl) piperidine-1-carboxamide (1) is a potent calcitonin gene-related peptide (CGRP) receptor antagonist. We have developed a convergent, stereoselective, and economical synthesis of the hydrochloride salt of 1 and demonstrated the synthesis on a multikilogram scale. Two different routes to the chiral indazolyl amino ester subunit were developed utilizing either a Rh-catalyzed asymmetric hydrogenation or a biocatalytic process to install the single chiral center. The advantages and disadvantages of each of these process routes are discussed, as are challenges addressed in the assembly of the final drug substance.