1415328-10-7Relevant articles and documents
Synthesis and Evaluation of Fluorine-18 Labeled 2-Phenylquinoxaline Derivatives as Potential Tau Imaging Agents
Zhou, Kaixiang,Yang, Fan,Li, Yuying,Chen, Yimin,Zhang, Xiaojun,Zhang, Jinming,Wang, Junfeng,Dai, Jiapei,Cai, Lisheng,Cui, Mengchao
, p. 1176 - 1195 (2021/02/06)
In this study, three pairs of optically pure 18F-labeled 2-phenylquinoxaline derivatives were evaluated as Tau imaging agents for the diagnosis of Alzheimer's disease (AD). The chiral 2-fluoromethyl-1,2-ethylenediol side chain was attached to the 2-phenyl
Mesogenic heterocycles derived from quinoxaline Schiff Bases
Kuo, Hsiu-Ming,Ko, Wan-Ping,Hsu, Yu-Te,Lee, Gene-Hsiang,Lai, Chung K.
, p. 6321 - 6333 (2016/09/23)
Three new series of heterocyclic quinoxaline Schiff Bases 1–2 were prepared, characterized and their mesomorphic properties were investigated. These compounds 1 and 2 are in fact geometric isomers in which an imine moiety (e.g., [sbnd]C[dbnd]N) is inversely incorporated into quinoxaline, leading to an opposite local dipole. Two single crystallographic structures 1 (m=8, n=8) and 2a (m=12, n=8) were determined by X-ray crystallographic analysis in order to understand the effect of mesomorphic properties. Weak H-bonds, CH–π and π–π interactions were found in both crystals, which were attributed to the formation of mesomorphic behavior. Variable temperature FT-IR experiments were performed to confirm the induced H-bonds. All series?of compounds 1–2 exhibited N/SmC or SmC phases, which were identified by optical microscope and confirmed by powder X-ray diffraction experiments. Compounds 2a have a slightly wider range of mesophase temperatures than that of compounds 1 and 2b.
