1415387-93-7

Basic information

• Product Name: 3-(4-chlorophenyl)-1-(cis-3,5-dimethylpiperidin-1-yl)-3-(2-hydroxy-4,6-dimethoxyphenyl)propan-1-one
• CAS NO: 1415387-93-7
• Molecular Weight: 431.959
• Mol File: 1415387-93-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 3-(4-chlorophenyl)-1-(cis-3,5-dimethylpiperidin-1-yl)-3-(2-hydroxy-4,6-dimethoxyphenyl)propan-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(4-chlorophenyl)-1-(cis-3,5-dimethylpiperidin-1-yl)-3-(2-hydroxy-4,6-dimethoxyphenyl)propan-1-one(1415387-93-7)
• EPA Substance Registry System: 3-(4-chlorophenyl)-1-(cis-3,5-dimethylpiperidin-1-yl)-3-(2-hydroxy-4,6-dimethoxyphenyl)propan-1-one(1415387-93-7)

Safety Data

• Hazardous Substances Data: 1415387-93-7(Hazardous Substances Data)

Upstream product

• 14446-75-4 (3S,5R)-3,5-dimethylpiperidine 
• 1151668-19-7 4-(4-chlorophenyl)-5,7-dimethoxychroman-2-one 
• 487-06-9 Limettin 
• 1679-18-1 4-Chlorophenylboronic acid 

Relevant articles and documents

Identification of potent and selective diphenylpropanamide RORγ inhibitors

Retinoic acid-related orphan receptor RORγt plays a pivotal role in the differentiation of TH17 cells. Antagonizing RORγt transcriptional activity is a potential means to treat TH17-related autoimmune diseases. Herein, we describe the identification of a series of diphenylpropanamides as novel and selective RORγ antagonists. Diphenylpropanamide 4n inhibited the transcriptional activity of RORγt, but not RORα, in cells. In addition, it suppressed human TH17 cell differentiation at submicromolar concentrations.