1415407-45-2Relevant articles and documents
Discovery of intestinal targeted TGR5 agonists for the treatment of type 2 diabetes
Duan, Hongliang,Ning, Mengmeng,Zou, Qingan,Ye, Yangliang,Feng, Ying,Zhang, Lina,Leng, Ying,Shen, Jianhua
, p. 3315 - 3328 (2015/05/05)
Activation of TGR5 stimulates intestinal glucagon-like peptide-1 (GLP-1) release, but activation of the receptors in gallbladder and heart has been shown to cause severe on-target side effects. A series of low-absorbed TGR5 agonists was prepared by modify