1415591-14-8

Basic information

• Product Name: C₂₇H₂₈N₂O₇
• CAS NO: 1415591-14-8
• Molecular Weight: 492.529
• Mol File: 1415591-14-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₇H₂₈N₂O₇(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₇H₂₈N₂O₇(1415591-14-8)
• EPA Substance Registry System: C₂₇H₂₈N₂O₇(1415591-14-8)

Safety Data

• Hazardous Substances Data: 1415591-14-8(Hazardous Substances Data)

Upstream product

• 1415591-03-5 2,6-bis(4-hydroxy-3-methoxyphenyl)piperidin-4-one 
• 121-33-5 vanillin 

Relevant articles and documents

Synthesis, antioxidant and antimicrobial activity of novel vanillin derived piperidin-4-one oxime esters: Preponderant role of the phenyl ester substituents on the piperidin-4-one oxime core

The study has been achieved the efficient synthesis of vanillin derived piperidin-4-one oxime esters (5a-m) via four step reaction involved Mannich reaction of vanillin, acetone and ammonium acetate to obtain 2,6-bis(4-hydroxy-3-methoxyphenyl)-piperidin-4-one 2 followed by N-methylation and oximation. Further, to enhance the biological activity of vanillin derived piperidin-4-one oxime core, esterification of 4 with substituted benzoyl chlorides in the presence of strong organic base t-BuOK accomplished a series of vanillin derived piperidin-4-one oxime esters (5a-m). The synthesized analogues are screened for their antioxidant and antimicrobial studies and the preponderant effect of the phenyl ester substituents on the biological activity of piperidin-4-one oxime core was demonstrated. Among the tested compounds, 5i and 5j are emerged as outperformed antioxidants than standard Butylated hydroxy anisole (BHA) whereas, compounds 5b and 5d manifested potent antibacterial and antifungal activity than standard streptomycin and fluconazole respectively.