1415657-99-6Relevant articles and documents
Macrocyclizations for medicinal chemistry: Synthesis of druglike macrocycles by high-concentration ullmann coupling
Collins, James C.,Farley, Kathleen A.,Limberakis, Chris,Liras, Spiros,Price, David,James, Keith
, p. 11079 - 11090 (2013/02/22)
Conditions have been identified for the efficient Ullmann macrocyclization of phenol and imidazole nucleophiles with aryl iodides at high reaction concentrations of up to 100 mM and using 5-10 mol % loading of an inexpensive copper catalyst. A range of substitution patterns and ring sizes are tolerated, and the method has been exemplified by the synthesis of a set of druglike macrocycles.