1415760-77-8

Basic information

• Product Name: 5-[4-[4-[5-cyano-1-(p-toluenesulfonyl)-1H-indol-3-yl]butyl]piperazin-1-yl]benzofuran-2-carboxamide
• Synonyms: 5-[4-[4-[5-cyano-1-(p-toluenesulfonyl)-1H-indol-3-yl]butyl]piperazin-1-yl]benzofuran-2-carboxamide
• CAS NO: 1415760-77-8
• Molecular Weight: 595.722
• Mol File: 1415760-77-8.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 5-[4-[4-[5-cyano-1-(p-toluenesulfonyl)-1H-indol-3-yl]butyl]piperazin-1-yl]benzofuran-2-carboxamide(CAS DataBase Reference)
• NIST Chemistry Reference: 5-[4-[4-[5-cyano-1-(p-toluenesulfonyl)-1H-indol-3-yl]butyl]piperazin-1-yl]benzofuran-2-carboxamide(1415760-77-8)
• EPA Substance Registry System: 5-[4-[4-[5-cyano-1-(p-toluenesulfonyl)-1H-indol-3-yl]butyl]piperazin-1-yl]benzofuran-2-carboxamide(1415760-77-8)

Safety Data

• Hazardous Substances Data: 1415760-77-8(Hazardous Substances Data)

Upstream product

• 15861-24-2 1H-indole-5-carbonitrile 
• 183288-46-2 5-(1-piperazinyl)benzofuran-2-carboxamide 
• 1398358-62-7 3-(4-chlorobutanoyl)-1-tosyl-1H-indole-5-carbonitrile 

Downstream Products

• 163521-12-8 vilazodone 

Relevant articles and documents

For the preparation of the compounds and intermediates thereof the vera assists the alkone and application

The invention belongs to the field of medicinal chemistry and relates to a compound for preparing vilazodone as well as an intermediate and an application thereof. The compound for preparing vilazodone is shown as a formula I, and the intermediate for synthesizing the compound of the formula I is shown as a formula II. The compound of the formula I can be applied to preparation of vilazodone and pharmaceutically acceptable salts thereof. The compound of the formula I serving as a novel intermediate is applied in preparation of the vilazodone, the defects in the conventional literature report are overcome, metal catalysts with high toxicity and organic phosphorus ligands thereof are avoided, the preparation cost is greatly reduced, the operation is simplified, and the compound is stable and controllable in quality and suitable for large-scale industrial preparation.

PROCESS FOR PREPARATION OF VILAZODONE, NOVEL INTERMEDIATES THEREOF AND NOVEL CRYSTALLINE FORM THEREOF

The invention relates to process for preparation of Vilazodone and novel intermediates for synthesis of Vilazodone. The invention also relates to novel crystalline form of Vilazodone hydrochloride and process for preparation thereof.