14159-48-9 Usage
Description
Propane-2-sulphonic acid, also known as 2-sulfopropane or 2-sulfopropylsulfonic acid, is an alkanesulfonic acid in which the sulfonic acid group is attached to a propan-2-yl group. It possesses strong acidic properties due to the presence of the sulfonic acid group, making it a versatile compound in various applications.
Uses
Used in Chemical Synthesis:
Propane-2-sulphonic acid is used as a reagent in chemical synthesis for its strong acidic properties, which can facilitate various reactions and improve the yield of desired products.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, propane-2-sulphonic acid is used as a buffering agent in the formulation of drugs. Its strong acidic nature allows it to maintain a stable pH environment, which is crucial for the stability and efficacy of certain medications.
Used in Analytical Chemistry:
Propane-2-sulphonic acid is employed as a mobile phase additive in high-performance liquid chromatography (HPLC) and other analytical techniques. Its acidic properties help in the separation and identification of various compounds, making it a valuable tool in research and quality control.
Used in Environmental Applications:
In environmental applications, propane-2-sulphonic acid can be used as a component in the treatment of wastewater. Its strong acidity can help in the removal of pollutants and heavy metals, contributing to a cleaner and safer environment.
Used in Material Science:
In material science, propane-2-sulphonic acid can be used as a modifying agent to alter the properties of polymers and other materials. Its acidic nature can facilitate the formation of new bonds and improve the overall performance of the material.
Overall, propane-2-sulphonic acid is a versatile compound with a wide range of applications across various industries, thanks to its strong acidic properties and ability to interact with different types of molecules.
Check Digit Verification of cas no
The CAS Registry Mumber 14159-48-9 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,4,1,5 and 9 respectively; the second part has 2 digits, 4 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 14159-48:
(7*1)+(6*4)+(5*1)+(4*5)+(3*9)+(2*4)+(1*8)=99
99 % 10 = 9
So 14159-48-9 is a valid CAS Registry Number.
InChI:InChI=1/C3H8O3S/c1-3(2)7(4,5)6/h3H,1-2H3,(H,4,5,6)
14159-48-9Relevant articles and documents
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Zuffanti
, p. 1044 (1940)
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Selective Late-Stage Sulfonyl Chloride Formation from Sulfonamides Enabled by Pyry-BF4
Gómez-Palomino, Alejandro,Cornella, Josep
supporting information, p. 18235 - 18239 (2019/11/13)
Reported here is a simple and practical functionalization of primary sulfonamides, by means of a pyrylium salt (Pyry-BF4), with nucleophiles. This simple reagent activates the poorly nucleophilic NH2 group in a sulfonamide, enabling the formation of one of the best electrophiles in organic synthesis: a sulfonyl chloride. Because of the variety of primary sulfonamides in pharmaceutical contexts, special attention has been focused on the direct conversion of densely functionalized primary sulfonamides by a late-stage formation of the corresponding sulfonyl chloride. A variety of nucleophiles could be engaged in this transformation, thus permitting the synthesis of complex sulfonamides, sulfonates, sulfides, sulfonyl fluorides, and sulfonic acids. The mild reaction conditions and the high selectivity of Pyry-BF4 towards NH2 groups permit the formation of sulfonyl chlorides in a late-stage fashion, tolerating a preponderance of sensitive functionalities.
The reaction of mercaptans with dimethyldioxirane. A facile synthesis of alkanesulfinic acids
Gu,Harpp
, p. 67 - 70 (2007/10/02)
Dimethyldioxirae oxidizes aliphatic thiols to sulfinic acids in very good yield. Benzylic and aromatic thiols give a variety of other oxidation products using DMD.
MECHANISTIC VARIATION IN ALKANESULFONYL CHLORIDE HYDROLYSIS AND RELATED REACTIONS
King, J. F.,Lam, J. Y. L.,Skonieczny, S.
, p. 177 - 180 (2007/10/02)
Kinetic and product ratio studies are consistent with the following mechanisms for the hydrolysis of methanesulfonyl chloride: (a) in acidic medium (pH 1-6) via a direct substitution on sulfur (SN2-S), (b) in mildly basic medium (pH 8-10) by way of sulfene (CH2=SO2) formation followed by trapping with water, and (c) in strongly basic solution (pH >10) via sulfene with trapping by the hydroxide ion.The reactions of primary and secondary alkanesulfonyl chlorides are qualitatively similar.
