14160-91-9

Basic information

• Product Name: 4,6-DICHLORO-2-METHYLPYRIMIDINE-5-CARBALDEHYDE
• Synonyms: 4,6-DICHLORO-2-METHYLPYRIMIDINE-5-CARBALDEHYDE;4,6-Dichloro-2-methyl-5-pyrimidinecarbaldehyde;4,6-Dichloro-2-Methyl-5-pyriMidinecarboxaldehyde
• CAS NO: 14160-91-9
• Molecular Formula: C₆H₄Cl₂N₂O
• Molecular Weight: 191.02
• EINECS: 604-604-1
• Mol File: 14160-91-9.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 276.2 °C at 760 mmHg
• Flash Point: 120.8 °C
• Appearance: /
• Density: 1.495 g/cm³
• Storage Temp.: Inert atmosphere,Store in freezer, under -20°C
• PKA: -5.44±0.39(Predicted)
• CAS DataBase Reference: 4,6-DICHLORO-2-METHYLPYRIMIDINE-5-CARBALDEHYDE(CAS DataBase Reference)
• NIST Chemistry Reference: 4,6-DICHLORO-2-METHYLPYRIMIDINE-5-CARBALDEHYDE(14160-91-9)
• EPA Substance Registry System: 4,6-DICHLORO-2-METHYLPYRIMIDINE-5-CARBALDEHYDE(14160-91-9)

Safety Data

• Hazardous Substances Data: 14160-91-9(Hazardous Substances Data)

Usage

General Description

4,6-Dichloro-2-Methylpyrimidine-5-Carbaldehyde is a chemical compound which may be characterized by its high reactivity, due to the presence of multiple reactive halogen and aldehyde groups on its molecular structure. It belongs to the family of Pyrimidines and derivatives, which are compounds containing a pyrimidine ring, a six-member aromatic heterocycle made of nitrogen, carbon, and hydrogen. The detailed study encompassing its synthesis, behavior and uses is subject to scientific research in the field of organic chemistry. It may have potential applications in a variety of fields, including pharmacology or agrochemical research, as a building block in the synthesis of complex molecules, especially where the presence of halogen atoms is required. However, as with any chemicals, appropriate precautions must be taken when handling 4,6-Dichloro-2-Methylpyrimidine-5-Carbaldehyde, to prevent harm or adverse reactions. Quite often it is used as an intermediate in the creation of more complex chemical compounds.

Upstream product

• 1194-22-5 2-methyl-4,6-dihydroxypyrimidine 
• 15263-76-0 N-((4,6-dihydroxy-2-methylpyrimidin-5-yl)methylene)-N-methylmethanaminium chloride 
• 1780-26-3 2,4-dichloro-2-methylpyrimidine 
• 67242-59-5 N-methyl-N-(2-pyridyl)-formamide 
• 68-12-2 N,N-dimethyl-formamide 

Downstream Products

• 1338327-19-7 6-(4-bromophenyl)-4-chloro-2-methyl-7,8-dihydropyrimido[5,4-f][1,4]oxazepin-5(6H)-one 
• 1338327-20-0 N-(4-bromophenyl)-4,6-dichloro-N-(2-hydroxyethyl)-2-methylpyrimidine-5-carboxamide 
• 1338327-21-1 N-(4-bromophenyl)-N-(2-(tert-butyldimethylsilyloxy)ethyl)-4,6-dichloro-2-methylpyrimidine-5-carboxamide 
• 1338326-64-9 4-amino-6-(2'-chlorobiphenyl-4-yl)-2-methyl-7,8-dihydropyrimido[5,4-f][1,4]oxazepin-5(6H)-one 
• 1338327-18-6 4-amino-6-(4-bromophenyl)-2-methyl-7,8-dihydropyrimido[5,4-f][1,4]oxazepin-5(6H)-one 
• 1269116-63-3 5-ethoxy-N-[1-(hydroxyacetyl)piperidin-4-yl]-2,7-dimethyl-4-oxo-3-(2-oxo-2-phenylethyl)-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidine-6-carboxamide 
• 1269116-61-1 N-[1-(hydroxyacetyl)piperidin-4-yl]-2,7-dimethyl-4-oxo-3-(2-oxo-2-phenylethyl)-5-(2,2,2-trifluoroethoxy)-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidine-6-carboxamide 
• 30129-53-4 4-chloro-6-methylpyrazolo<3,4-d>pyrimidine 

Relevant articles and documents

SUBSTITUTED PYRIMIDINE FOR THE TREATMENT AND PROPHYLAXIS OF HEPATITIS B VIRUS INFECTION

The present invention provides novel compounds having the general formula: wherein R1 to R4, L1, L2 and X are as described herein, compositions including the compounds and methods of using the compounds.

PYRIMIDONE DERIVATIVES AS SELECTIVE CYTOTOXIC AGENTS AGAINST HIV INFECTED CELLS

The present disclosure is directed to pyrimidone derivatives of Formula I and their use for selectively killing HIV infected GAG-POL expressing cells without concomitant cytotoxicity to HIV nave cells, and for the treatment or prophylaxis of infection by HIV, or for the treatment, prophylaxis or delay in the onset or progression of AIDS or AIDS Related Complex (ARC).

Structure-based design of a novel series of potent, selective inhibitors of the class i phosphatidylinositol 3-kinases

A highly selective series of inhibitors of the class I phosphatidylinositol 3-kinases (PI3Ks) has been designed and synthesized. Starting from the dual PI3K/mTOR inhibitor 5, a structure-based approach was used to improve potency and selectivity, resulting in the identification of 54 as a potent inhibitor of the class I PI3Ks with excellent selectivity over mTOR, related phosphatidylinositol kinases, and a broad panel of protein kinases. Compound 54 demonstrated a robust PD-PK relationship inhibiting the PI3K/Akt pathway in vivo in a mouse model, and it potently inhibited tumor growth in a U-87 MG xenograft model with an activated PI3K/Akt pathway.