1416015-41-2

Basic information

• Product Name: C₁₃H₇Cl₃OS
• Synonyms: C₁₃H₇Cl₃OS
• CAS NO: 1416015-41-2
• Molecular Weight: 317.623
• Mol File: 1416015-41-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₁₃H₇Cl₃OS(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₃H₇Cl₃OS(1416015-41-2)
• EPA Substance Registry System: C₁₃H₇Cl₃OS(1416015-41-2)

Safety Data

• Hazardous Substances Data: 1416015-41-2(Hazardous Substances Data)

Upstream product

• 36157-40-1 3-acetyl-2,5-dichlorothiophene 
• 104-88-1 4-chlorobenzaldehyde 

Downstream Products

• 1416015-29-6 C₁₄H₁₀Cl₃N₃S₂ 
• 1416015-19-4 C₂₂H₁₃Cl₄N₃S₂ 

Relevant articles and documents

The synthesis, characterization, cytotoxic activity assessment and structure-activity relationship of 4-aryl-6-(2,5-dichlorothiophen-3-yl)-2-methoxypyridine-3-carbonitriles

A series of 2-methoxypyridine-3-carbonitrile (5a-i)-bearing aryl substituents were successfully synthesized in good yields by the condensation of chalcones (4a-i) with malononitrile in basic medium. The condensation process, in most cases, offers a route to a variety of methoxypyridine derivatives (6a-g) as side products in poor yields. All new compounds were fully characterized using different spectroscopic methods. Mass ESI-HMRS measurements were also performed. Furthermore, these compounds were screened for their in vitro cytotoxicity activities against three cancer cell lines; namely, those of the liver (line HepG2), prostate (line DU145) and breast (line MBA-MB-231). The cytotoxicity assessment revealed that compounds 5d, 5g, 5h and 5i exhibit promising antiproliferative effects (IC50 1-5 μM) against those three cancer cell lines.