1416253-42-3

Basic information

• Product Name: tert-butyl (4-hydroxy-4-methyl-1-(2-oxodihydrofuran-3-ylidene)pentan-2-yl)carbamate
• Synonyms: tert-butyl (4-hydroxy-4-methyl-1-(2-oxodihydrofuran-3-ylidene)pentan-2-yl)carbamate
• CAS NO: 1416253-42-3
• Molecular Weight: 379.499
• Mol File: 1416253-42-3.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: tert-butyl (4-hydroxy-4-methyl-1-(2-oxodihydrofuran-3-ylidene)pentan-2-yl)carbamate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-butyl (4-hydroxy-4-methyl-1-(2-oxodihydrofuran-3-ylidene)pentan-2-yl)carbamate(1416253-42-3)
• EPA Substance Registry System: tert-butyl (4-hydroxy-4-methyl-1-(2-oxodihydrofuran-3-ylidene)pentan-2-yl)carbamate(1416253-42-3)

Safety Data

• Hazardous Substances Data: 1416253-42-3(Hazardous Substances Data)

Upstream product

• 100-39-0 benzyl bromide 
• 34932-07-5 3-(triphenylphosphoranyliden)dihydro-2(3H)-furanone 
• 1416253-40-1 tert-butyl (4-hydroxy-4-methyl-1-(2-oxodihydrofuran-3-ylidene)pentan-2-yl)carbamate 
• 1416253-35-4 (S)-tert-butyl (1,4-dihydroxy-4-methylpentan-2-yl)carbamate 
• 136703-59-8 (3S)-3-[(tert-butoxycarbonyl)amino]-4-hydroxybutanoic acid methyl ester 

Relevant articles and documents

A concise and scalable formal synthesis of the enantiopure side-chain diester of homoharringtonine

The enantiopure side-chain diester of homoharringtonine (HHT) has been prepared in 38% overall yield, from cheap L-aspartic acid by a linear sequence of 10 chemical operations (mean yield per step: 91%). The experimental operation in each step is convenient, economic and prone to scale up. About 7-10 g of the side-chain diester of HHT is easily prepared within one week from 5 g of L-aspartic acid.