141626-57-5

Basic information

• Product Name: N-(2-butyl-3-(4-(3-(dibutylamino)propoxy)-benzoyl)benzofuran-5-yl)-N-(methylsulfonyl)methanesulfonamide
• Synonyms: N-(2-butyl-3-(4-(3-(dibutylamino)propoxy)-benzoyl)benzofuran-5-yl)-N-(methylsulfonyl)methanesulfonamide
• CAS NO: 141626-57-5
• Molecular Weight: 634.858
• Mol File: 141626-57-5.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: N-(2-butyl-3-(4-(3-(dibutylamino)propoxy)-benzoyl)benzofuran-5-yl)-N-(methylsulfonyl)methanesulfonamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(2-butyl-3-(4-(3-(dibutylamino)propoxy)-benzoyl)benzofuran-5-yl)-N-(methylsulfonyl)methanesulfonamide(141626-57-5)
• EPA Substance Registry System: N-(2-butyl-3-(4-(3-(dibutylamino)propoxy)-benzoyl)benzofuran-5-yl)-N-(methylsulfonyl)methanesulfonamide(141626-57-5)

Safety Data

• Hazardous Substances Data: 141626-57-5(Hazardous Substances Data)

Usage

Description

N-(2-butyl-3-(4-(3-(dibutylamino)propoxy)-benzoyl)benzofuran-5-yl)-N-(methylsulfonyl)methanesulfonamide is a complex organic compound with a unique chemical structure. It is characterized by its benzofuran core, which is substituted with various functional groups, including a butyl group, a benzoyl group, and a methanesulfonamide group. N-(2-butyl-3-(4-(3-(dibutylamino)propoxy)-benzoyl)benzofuran-5-yl)-N-(methylsulfonyl)methanesulfonamide is likely to have specific properties and applications due to its intricate molecular structure.

Uses

1. Pharmaceutical Industry:
N-(2-butyl-3-(4-(3-(dibutylamino)propoxy)-benzoyl)benzofuran-5-yl)-N-(methylsulfonyl)methanesulfonamide is used as an impurity in the production of Dronedarone (D679445, HCl), a drug prescribed for the treatment of atrial fibrillation and atrial flutter in patients experiencing cardiac arrhythmias. The presence of this compound as an impurity may affect the drug's efficacy and safety, making it crucial to monitor and control its levels during the manufacturing process.
2. Research and Development:
Due to its unique chemical structure, N-(2-butyl-3-(4-(3-(dibutylamino)propoxy)-benzoyl)benzofuran-5-yl)-N-(methylsulfonyl)methanesulfonamide may also be used in research and development for various applications, such as the synthesis of new compounds, the study of its chemical properties, or the investigation of its potential biological activities. Further research may reveal additional uses and applications for this compound in different industries.

Upstream product

• 500791-70-8 5-amino-2-n-butyl-3-[4-(3-di-n-butylamino propoxy)benzoyl]benzofuran bisoxalate 
• 124-63-0 methanesulfonyl chloride 
• 141644-91-9 (5-amino-2-butyl-benzofuran-3-yl)-[4-(3-dibutylamino-propoxy)-phenyl]-methanone 
• 100-07-2 4-methoxy-benzoyl chloride 
• 141627-42-1 (2-butyl-5-nitrobenzofuran-3-yl)(4-methoxyphenyl)methanone 
• 133238-87-6 2-(n-butyl)-5-nitrobenzofuran 
• 1323367-35-6 5-fluoro-2-butylbenzofuran 
• 497225-66-8 2-n-butyl-5-bromo-benzofuran 
• 108920-07-6 2-(2-formyl-4-chlorophenoxy)hexanoic acid 
• 1323367-31-2 methyl 2-(4-chloro-2-formyl-phenoxy)hexanoate 
• 55877-57-1 2-butyl-5-chlorobenzo[b]furan 
• 141645-51-4 5-amino 2-n-butyl benzofuran 
• 591-78-6 n-hexan-2-one 
• 635-93-8 5-chlorosalicyclaldehyde 

Downstream Products

• 141626-36-0 dronedarone 

Relevant articles and documents

Identification and characterization of potential impurities of dronedarone hydrochloride

Six potential process related impurities were detected during the impurity profile study of an antiarrhythmic drug substance, Dronedarone (1). Simple high performance liquid chromatography and liquid chromatography-mass spectrometry methods were used for the detection of these process impurities. Based on the synthesis and spectral data (MS, IR, 1H NMR, 13C NMR, and DEPT), the structures of these impurities were characterized a s 5-amino-3-[4-(3-di-n-butylaminopropoxy)benzoyl]-2-n-butylbenzofuran (impurity I); N-(2-butyl-3-(4-(3-(dibutylamino)propoxy)-benzoyl)benzofuran-5-yl)-N- (methylsulfonyl)-methanesulfonamide (impurity II); N-(2-butyl-3-(4-(3- (dibutylamino)propoxy)benzoyl)benzofuran-5-yl)-1-chloromethanesulfonamide (impurity III); N-{2-propyl-3-[4-(3-dibutylaminopropoxy)benzoyl]benzofuran-5-yl} - methanesulfonamide (impurity IV); N-(2-butyl-3-(4-(3-(dibutylamino)propoxy) benzoyl)benzofuran-5-yl)-formamide (impurity V); and (2-butyl-5-((3- (dibutylamino)propyl)amino)benzofuran-3-yl)(4-(3- (dibutylamino)propoxy)phenyl) methanone (impurity VI). The synthesis and characterization of these impurities are discussed in detail.

PREPARATION OF BENZOFURANS AND USE THEREOF AS SYNTHETIC INTERMEDIATES

The present invention provides several synthetic methods for preparing N-(2-butylbenzofuran-5-yl)-N-(methylsulfonyl)methanesulfonamide, a compound of formula (3), an intermediate in the preparation of Dronedarone. The present invention further provides a process for preparing Dronedarone, comprising the steps of converting 2-butyl-5-bis(methanesulfon)-amidobenzofuran of formula (3) to Dronedarone, wherein the 2-butyl-5-bis(methanesulfon)-amidobenzofuran of formula (3) is prepared by the processes of the present invention.