1416316-24-9

Basic information

• Product Name: 4-((7-([1,1'-biphenyl]-2-ylamino)benzo[c][1,2,5]oxadiazol-4-yl)amino)-4-oxobutanoic acid
• Synonyms: 4-((7-([1,1'-biphenyl]-2-ylamino)benzo[c][1,2,5]oxadiazol-4-yl)amino)-4-oxobutanoic acid
• CAS NO: 1416316-24-9
• Molecular Weight: 402.409
• Mol File: 1416316-24-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4-((7-([1,1'-biphenyl]-2-ylamino)benzo[c][1,2,5]oxadiazol-4-yl)amino)-4-oxobutanoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 4-((7-([1,1'-biphenyl]-2-ylamino)benzo[c][1,2,5]oxadiazol-4-yl)amino)-4-oxobutanoic acid(1416316-24-9)
• EPA Substance Registry System: 4-((7-([1,1'-biphenyl]-2-ylamino)benzo[c][1,2,5]oxadiazol-4-yl)amino)-4-oxobutanoic acid(1416316-24-9)

Safety Data

• Hazardous Substances Data: 1416316-24-9(Hazardous Substances Data)

Upstream product

• 10199-89-0 NBD chloride 
• 90-41-5 2-phenylaniline 
• 1416316-21-6 N-4-[(1,1'-biphenyl)-2-yl]benzo[c][1,2,5]oxadiazole-4,7-diamine 
• 4938-01-6 succinic acid monochloride 
• 413611-93-5 N-([1,1'-biphenyl]-2-yl)-7-nitrobenzo[c][1,2,5]oxadiazol-4-amine 

Relevant articles and documents

Pharmacophore identification of c-Myc inhibitor 10074-G5

A structure-activity relationship (SAR) study of the c-Myc (Myc) inhibitor 10074-G5 (N-([1,1′-biphenyl]-2-yl)-7-nitrobenzo[c][1,2,5]oxadiazol-4- amine, 1) - which targets a hydrophobic domain of the Myc oncoprotein that is flanked by arginine residues - was executed in order to determine its pharmacophore. Whilst the 7-nitrobenzofurazan was found to be critical for inhibitory activity, the ortho-biphenyl could be replaced with a para-carboxyphenyl group to furnish the new inhibitor JY-3-094 (3q). Around five times as potent as the lead with an IC50 of 33 μM for disruption of the Myc-Max heterodimer, JY-3-094 demonstrated excellent selectivity over Max-Max homodimers, with no apparent effect at 100 μM. Importantly, the carboxylic acid of JY-3-094 improves the physicochemical properties of the lead compound, which will facilitate the incorporation of additional hydrophobicity that might enhance Myc inhibitory activity further still.