1416319-50-0Relevant articles and documents
Regiocontrolled functionalization of 2,3-dihalogenoimidazo[1,2-a]pyridines by Suzuki-Miyaura and Sonogashira cross-coupling reactions
Delaye,Pénichon,Allouchi,Enguehard-Gueiffier,Gueiffier
, p. 4199 - 4203 (2017/07/10)
An efficient method for regiocontrolled functionalization of 2,3-dihalogenoimidazo[1,2-a]pyridine was developed. This sequence allowed the selective introduction of aryl, heteroaryl, alkyl and alkynyl substituents at both 2- and 3-positions, by using Suzu
Synthesis and biological evaluation of 2,3-diarylimidazo[1,2-a]pyridines as antileishmanial agents
Marhadour, Sophie,Marchand, Pascal,Pagniez, Fabrice,Bazin, Marc-Antoine,Picot, Carine,Lozach, Olivier,Ruchaud, Sandrine,Antoine, Maud,Meijer, Laurent,Rachidi, Najma,Le Pape, Patrice
, p. 543 - 556 (2013/02/23)
A novel series of 2,3-diarylimidazo[1,2-a]pyridines was synthesized and evaluated for their antileishmanial activities. Four derivatives exhibited good activity against the promastigote and intracellular amastigote stages of Leishmania major, coupled with a low cytotoxicity against the HeLa human cell line. The impact of compound lipophilicity on antiparasitic activities was investigated by Log D comparison. Although LmCK1 could be the parasitic target for three compounds (13, 18, 21), the inhibition of another target is under study to explain the antileishmanial effect of the most promising compounds.