1416439-95-6

Basic information

• Product Name: 8-(trifluoromethyl)[1,2,4]triazolo[1,5-a]pyridin-2-amine
• CAS NO: 1416439-95-6
• Molecular Weight: 202.139
• Mol File: 1416439-95-6.mol
• Article Data: 1

Chemical Properties

• Density: 1.69±0.1 g/cm3(Predicted)
• CAS DataBase Reference: 8-(trifluoromethyl)[1,2,4]triazolo[1,5-a]pyridin-2-amine(CAS DataBase Reference)
• NIST Chemistry Reference: 8-(trifluoromethyl)[1,2,4]triazolo[1,5-a]pyridin-2-amine(1416439-95-6)
• EPA Substance Registry System: 8-(trifluoromethyl)[1,2,4]triazolo[1,5-a]pyridin-2-amine(1416439-95-6)

Safety Data

• Hazardous Substances Data: 1416439-95-6(Hazardous Substances Data)

Upstream product

• 65753-47-1 2-chloro-3-trifluoromethyl-pyridine 

Relevant articles and documents

Oxidative cyclization of 1-(pyridin-2-yl)guanidine derivatives: A synthesis of [1,2,4]triazolo[1,5-a]pyridin-2-amines and an unexpected synthesis of [1,2,4]triazolo[4,3-a]pyridin-3-amines

Oxidative cyclization of 1-(pyridin-2-yl)guanidine derivatives using N-chlorosuccinimide and aqueous potassium carbonate has been investigated. Chlorination of 1-(5-nitropyridin-2-yl)guanidine by N-chlorosuccinimide in methanol followed by addition of aqueous potassium carbonate gave rise to cyclization and afforded 6-nitro-[1,2,4]triazolo[1,5-a]pyridin-2-amine in one-pot. In the course of studying the scope and limitation of the reaction, it was found that some of the examined 1-(pyridin-2-yl)guanidine derivatives gave not only the desired [1,2,4]triazolo[1,5-a]pyridin-2-amines but also unexpected [1,2,4]triazolo[4,3-a]pyridin-3-amine products. As plausible reaction mechanisms of this oxidative cyclization, diazirine formation and nitrene formation are presented.