1416778-31-8

Basic information

• Product Name: methyl 2-(4-nitrophenyl)-5-oxo-4-(tri-2-thienyl-λ⁵-phosphanylidene)-4,5-dihydrofuran-3-carboxylate
• CAS NO: 1416778-31-8
• Molecular Weight: 541.566
• Mol File: 1416778-31-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: methyl 2-(4-nitrophenyl)-5-oxo-4-(tri-2-thienyl-λ⁵-phosphanylidene)-4,5-dihydrofuran-3-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 2-(4-nitrophenyl)-5-oxo-4-(tri-2-thienyl-λ⁵-phosphanylidene)-4,5-dihydrofuran-3-carboxylate(1416778-31-8)
• EPA Substance Registry System: methyl 2-(4-nitrophenyl)-5-oxo-4-(tri-2-thienyl-λ⁵-phosphanylidene)-4,5-dihydrofuran-3-carboxylate(1416778-31-8)

Safety Data

• Hazardous Substances Data: 1416778-31-8(Hazardous Substances Data)

Upstream product

• 24171-89-9 tris(2-thienyl)phosphine 
• 555-16-8 4-nitrobenzaldehdye 
• 762-42-5 dimethyl acetylenedicarboxylate 

Relevant articles and documents

Assembly of dimethyl acetylenedicarboxylate and phosphanes with aldehydes leading to γ-lactones bearing α-phosphorus ylides as wittig reagents

We report herein a convenient route to the synthesis of aryl-substituted γ-lactones bearing an α-phosphorus ylide moiety through the assembly of dimethyl acetylenedicarboxylate (DMAD), electron-deficient aldehydes, and triaryl-or trialkylphosphanes in moderate to good yields. The formation of γ-lactones is highly dependent on the reaction time, the phosphane nucleophile, and the molar ratio of DMAD, aldehyde, and phosphane. We found that reactions with a DMAD/aldehyde/tri-p-tolylphosphane molar ratio of 3:1:6 and more electron-deficient aldehydes, such as 4-nitrobenzaldehyde and 4-chloro-3-nitrobenzaldehyde, gave good yields. The isolated ylides reacted with aldehydes as Wittig reagents to give olefins in moderate yields.