141684-85-7

Basic information

• Product Name: Inosine, 2',3'-dideoxy-5'-O-[(1,1-dimethylethyl)diphenylsilyl]-
• CAS NO: 141684-85-7
• Molecular Formula: C26H30N4O3Si
• Molecular Weight: 474.635
• Mol File: 141684-85-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Inosine, 2',3'-dideoxy-5'-O-[(1,1-dimethylethyl)diphenylsilyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: Inosine, 2',3'-dideoxy-5'-O-[(1,1-dimethylethyl)diphenylsilyl]-(141684-85-7)
• EPA Substance Registry System: Inosine, 2',3'-dideoxy-5'-O-[(1,1-dimethylethyl)diphenylsilyl]-(141684-85-7)

Safety Data

• Hazardous Substances Data: 141684-85-7(Hazardous Substances Data)

Upstream product

• 32780-06-6 (5S)-5-(hydroxymethyl)-2-oxo-tetrahydrofuran 
• 58479-61-1 tert-butylchlorodiphenylsilane 
• 141684-81-3 6-chloro-9-<5-O-(tert-butyldiphenylsilyl)-3-deoxy-2-Se-phenyl-2-seleno-β-D-erythro-pentofuranosyl>-9H-purine 
• 115728-44-4 5-O-(tert-butyldiphenylsilyl)-3-deoxy-2-Se-phenyl-2-seleno-D-erythro-pentonic acid γ-lactone 
• 125440-13-3 (S)-2-(tert-Butyl-diphenyl-silanyloxymethyl)-5-trimethylsilanyloxy-2,3-dihydro-furan 
• 102717-29-3 (5S)-5-({[tert-butyl(diphenyl)silyl]oxy}methyl)dihydrofuran-2(3H)-one 
• 149656-26-8 1-O-acetyl-5-O-(tert-butyldiphenylsilyl)-2,3-dideoxy-2-(phenylselenenyl)-D-erythro-pentafuranose 
• 141706-88-9 9-<5-O-(tert-butyldiphenylsilyl)-3-deoxy-2-Se-phenyl-2-seleno-β-D-erythro-pentofuranosyl>hypoxanthine 

Downstream Products

• 69655-05-6 Dideoxyinosine 

Relevant articles and documents

A Highly Stereoselective Synthesis of Anti-HIV 2',3'-Dideoxy- and 2',3'-Didehydro-2',3'-dideoxynucleosides

A general total synthesic method for the stereocontrolled synthesis of 2',3'-dideoxy- as well as 2',3'-didehydro-2',3'-dideoxynucleosides is presented.Introduction of an α-phenylselenenyl group at the 2-position of 2,3-dideoxyribosyl acetate directs the glycosyl bond formation to give >/=95percent β-isomer.This 2'-phenylselenenyl nucleoside may be converted to either the 2',3'-dideoxynucleoside by treatment with n-Bu3SnH and Et3B at room temperature or to the unsaturated derivative by treatment with H2O2/cat. pyridine.The application of this method to the syntheses of pyrimidines (ddU, ddT, ddC), 6-substituted purines (ddA, ddI, 6-chloro-ddP, N6-Me-ddA), and 2,6-disubstituted purines (2-F-ddA, 6-chloro-2-amino-ddP) as well as selected 2',3'-didehydro-2',3'-dideoxy derivatives is reported.