1416969-58-8

Basic information

• Product Name: 2-(2,6-dimethylphenyl)-1H-indole
• CAS NO: 1416969-58-8
• Molecular Weight: 221.302
• Mol File: 1416969-58-8.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 2-(2,6-dimethylphenyl)-1H-indole(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(2,6-dimethylphenyl)-1H-indole(1416969-58-8)
• EPA Substance Registry System: 2-(2,6-dimethylphenyl)-1H-indole(1416969-58-8)

Safety Data

• Hazardous Substances Data: 1416969-58-8(Hazardous Substances Data)

Upstream product

• 36268-59-4 N-(2-(cyanomethyl)phenyl)acetamide 
• 100379-00-8 2,6-dimethylbenzene boronic acid 
• 2142-76-9 2',6'-dimethylacetophenone 
• 59-88-1 phenylhydrazine hydrochloride 

Relevant articles and documents

The Development of a Palladium-Catalyzed Tandem Addition/Cyclization for the Construction of Indole Skeletons

A palladium-catalyzed tandem addition/cyclization of 2-(2-aminoaryl)acetonitriles with arylboronic acids has been developed for the first time, achieving a new strategy for direct construction of indole skeletons. This system shows good functional group tolerance and remarkable chemoselectivity. In particular, the halogen (e.g., bromo and iodo) substituents are amenable to further synthetic elaborations thereby broadening the diversity of the products. Preliminary mechanistic experiments indicate that this transformation involves sequential nucleophilic addition followed by an intramolecular cyclization.