1416992-43-2

Basic information

• Product Name: C₂₄H₂₈N₃O₈S^(1-)*Na⁽¹⁺⁾
• Synonyms: C₂₄H₂₈N₃O₈S^(1-)*Na⁽¹⁺⁾
• CAS NO: 1416992-43-2
• Molecular Weight: 541.557
• Mol File: 1416992-43-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₄H₂₈N₃O₈S^(1-)*Na⁽¹⁺⁾(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₄H₂₈N₃O₈S^(1-)*Na⁽¹⁺⁾(1416992-43-2)
• EPA Substance Registry System: C₂₄H₂₈N₃O₈S^(1-)*Na⁽¹⁺⁾(1416992-43-2)

Safety Data

• Hazardous Substances Data: 1416992-43-2(Hazardous Substances Data)

Upstream product

• 1385184-07-5 C₂₄H₂₇N₃O₅ 
• 7524-50-7 methyl (2S)-2-amino-3-phenylpropanoate hydrochloride 
• 1385184-02-0 C₂₅H₂₉N₃O₆ 
• 1161-13-3 N-Cbz-L-Phe 
• 35909-92-3 N-carbobenzoxy-L-phenylalanine methyl ester 

Relevant articles and documents

Inhibition of norovirus 3CL protease by bisulfite adducts of transition state inhibitors

Noroviruses are the most common cause of acute viral gastroenteritis, accounting for >21 million cases annually in the US alone. Norovirus infections constitute an important health problem for which there are no specific antiviral therapeutics or vaccines. In this study, a series of bisulfite adducts derived from representative transition state inhibitors (dipeptidyl aldehydes and α-ketoamides) was synthesized and shown to exhibit anti-norovirus activity in a cell-based replicon system. The ED 50 of the most effective inhibitor was 60 nM. This study demonstrates for the first time the utilization of bisulfite adducts of transition state inhibitors in the inhibition of norovirus 3C-like protease in vitro and in a cell-based replicon system. The approach described herein can be extended to the synthesis of the bisulfite adducts of other classes of transition state inhibitors of serine and cysteine proteases, such as α-ketoheterocycles and α-ketoesters.