14171-89-2

Basic information

• Product Name: 6-PHENYL-HEXAN-2-ONE
• Synonyms: 6-PHENYL-HEXAN-2-ONE;1-Phenylhexane-5-one;6-Phenyl-2-hexanone;6-Phenylhexane-2-one
• CAS NO: 14171-89-2
• Molecular Formula: C₁₂H₁₆O
• Molecular Weight: 176.25484
• EINECS: 238-017-2
• Mol File: 14171-89-2.mol
• Article Data: 29

Chemical Properties

• Boiling Point: 299.9 °C at 760 mmHg
• Flash Point: 145 °C
• Appearance: /
• Density: 0.95 g/cm³
• Vapor Pressure: 0.00116mmHg at 25°C
• Refractive Index: 1.498
• CAS DataBase Reference: 6-PHENYL-HEXAN-2-ONE(CAS DataBase Reference)
• NIST Chemistry Reference: 6-PHENYL-HEXAN-2-ONE(14171-89-2)
• EPA Substance Registry System: 6-PHENYL-HEXAN-2-ONE(14171-89-2)

Safety Data

• Hazardous Substances Data: 14171-89-2(Hazardous Substances Data)

Usage

InChI:InChI=1/C12H16O/c1-11(13)7-5-6-10-12-8-3-2-4-9-12/h2-4,8-9H,5-7,10H2,1H3

Upstream product

• 86088-39-3 2-(5-phenylbutyl)oxirane 
• 5435-44-9 (E)-3-Ureido-but-2-enoic acid ethyl ester 
• 4173-44-8 1-phenyl-1,3-hexadien-5-one 
• 91368-25-1 6-phenylhex-3-en-5-yne-2-one 
• 32798-47-3 2-acetyl-5-phenyl-pentanoic acid ethyl ester 
• 4173-44-8 (E,E)-6-phenyl-3,5-hexadien-2-one 
• 60427-87-4 3-methoxy-7-phenyl-hept-2-enoic acid 
• 127047-14-7 5-hydroxy-1-phenyl-hexene-⁽¹⁾ 
• 591-50-4 iodobenzene 
• 17397-24-9 hex-5-en-2-ol 
• 120853-08-9 3-oxo-7-phenyl-heptanoic acid methyl ester 
• 3884-71-7 bromo-5-pentanone-2 
• 100-39-0 benzyl bromide 
• 100-42-5 styrene 

Downstream Products

• 2270-20-4 5-Phenylpentanoic acid 
• 739304-38-2 1-methyl-5-phenyl-pentylamine 
• 99742-12-8 (E)-1,7-diphenylhept-1-en-3-one 
• 87657-66-7 (E)-1-(3-hydroxy-4-methoxyphenyl)-7-phenylhept-1-en-3-one 
• 87657-69-0 (E)-1-(4-hydroxyphenyl)-7-phenylhept-1-en-3-one 
• 81840-57-5 1-(3-methoxy-4-hydroxyphenyl)-7-phenylhept-1-en-3-one 
• 87657-68-9 (E)-1-(3,4-dimethoxyphenyl)-7-phenylhept-1-en-3-one 
• 87657-70-3 (E)-1-(3-methoxyphenyl)-7-phenylhept-1-en-3-one 
• 87657-67-8 (E)-1-(3,4-dihydroxyphenyl)-7-phenyl-hept-1-en-3-one 
• 345619-40-1 4-Chlormethyl-2-methyl-2-(4-phenylbutyl)-1,3-dioxalan 
• 1026934-61-1 3-methyl-7-phenyl-hept-2-enoic acid tert-butyl ester 
• 608532-74-7 (+/-)-6-bromo-6-phenyl-2-hexanone 

Relevant articles and documents

Selective Decarbalkoxylation of β-Keto Esters

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Effects of lipophilicity, protecting group and stereochemistry on the antimalarial activity of carbohydrate-derived thiochromans

A series of novel carbohydrate-derived thiochromans has been successfully synthesized in order to investigate the influence of alkyl substituents on the aromatic ring of the thiophenol moiety in addition to the effect of protecting groups and stereochemistry on the sugar component of the target molecules. Results from the evaluation of the thiochromans for their antimalarial activity against the chloroquine-sensitive (3D7) strain of Plasmodium falciparum suggest that the presence of short chain alkyl substituents, a benzyl ether protecting group and equatorial orientation of the C-4 substituent on the sugar moiety are crucial structural features that impart high antimalarial activity.

Chiral isoxazolidine-mediated stereoselective umpolung α-phenylation of methyl ketones

An effective asymmetric α-phenylation of methyl ketones with triphenylaluminium in the presence of (+)-benzopyranoisoxazolidine has been developed. The reaction proceeds via the in situ formation of a chiral N-alkoxyenamine and the subsequent diastereoselective nucleophilic phenylation to provide α-phenylated products in moderate to good yields, with high enantioselectivities.