1417863-13-8

Basic information

• Product Name: 2-(1-adamantylmethyl)-5-(2-bromophenyl)-1,3,4-oxadiazole
• Synonyms: 2-(1-adamantylmethyl)-5-(2-bromophenyl)-1,3,4-oxadiazole
• CAS NO: 1417863-13-8
• Molecular Weight: 373.293
• Mol File: 1417863-13-8.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 2-(1-adamantylmethyl)-5-(2-bromophenyl)-1,3,4-oxadiazole(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(1-adamantylmethyl)-5-(2-bromophenyl)-1,3,4-oxadiazole(1417863-13-8)
• EPA Substance Registry System: 2-(1-adamantylmethyl)-5-(2-bromophenyl)-1,3,4-oxadiazole(1417863-13-8)

Safety Data

• Hazardous Substances Data: 1417863-13-8(Hazardous Substances Data)

Upstream product

• 29418-67-5 2-bromobenzohydrazide 
• 4942-47-6 (adamant-1-yl)-acetic acid 
• 610-94-6 2-bromobenzoic acid methyl ester 
• 88-65-3 2-bromobenzoic-acid 

Relevant articles and documents

Synthesis, crystal structure and anti-HIV activity of 2-adamantyl/ adamantylmethyl-5-aryl-1,3,4-oxadiazoles

Two series of 2-adamantyl/adamantylmethyl-5-aryl-1,3,4-oxadiazoles (4a-l and 5a-l) were synthesized by cyclodehydration of adamantan-1-carboxylic acid/adamantylacetic acid with various aryl hydrazides (3a-l) in the presence of POCl3. The synthesis was supported by spectroanalytical techniques and verified further by crystal structure determination of compounds 4e and 5k. The synthesized compounds were screened for their inhibitory activity against HIV-1 and HIV-2 in MT-4 cells. Compound 5b exhibited a moderate activity in vitro for the replication of both virus types, suggesting for further structural modification as a new lead in the development of an antiviral agent.