1418210-07-7

Basic information

• Product Name: ethyl 2-acetyl-5-(6-fluoro-1H-indol-3-yl)-5-(4-methoxyphenyl)pentanoate
• Synonyms: ethyl 2-acetyl-5-(6-fluoro-1H-indol-3-yl)-5-(4-methoxyphenyl)pentanoate
• CAS NO: 1418210-07-7
• Molecular Weight: 411.473
• Mol File: 1418210-07-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: ethyl 2-acetyl-5-(6-fluoro-1H-indol-3-yl)-5-(4-methoxyphenyl)pentanoate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 2-acetyl-5-(6-fluoro-1H-indol-3-yl)-5-(4-methoxyphenyl)pentanoate(1418210-07-7)
• EPA Substance Registry System: ethyl 2-acetyl-5-(6-fluoro-1H-indol-3-yl)-5-(4-methoxyphenyl)pentanoate(1418210-07-7)

Safety Data

• Hazardous Substances Data: 1418210-07-7(Hazardous Substances Data)

Upstream product

• 399-51-9 6-fluoro-1H-indole 
• 1301176-55-5 ethyl 2-(4-methoxyphenyl)-6-methyl-3,4-dihydro-2H-pyran-5-carboxylate 

Relevant articles and documents

Gluconic acid aqueous solution: A task-specific bio-based solvent for ring-opening reactions of dihydropyrans

Gluconic acid aqueous solution (GAAS) that is a largely available bio-based chemical was proved to be an effective task-specific medium for ring-opening reactions of dihydropyrans. In the presence of nucleophiles, such as indoles, 1,3-cyclohexanediones, N,N-dimethylaniline, N-methylaniline, 2-naphthol, and resorcin, a series of 2-substituted 1, 3-dicarbonyl compounds were synthesized in good to excellent yields. The first example of ring-opening of oxa-Pictet-Spengler product with nucleophiles was also described. These results not only demonstrate the feasibility of using GAAS as a sustainable solvent, but also offer an effective way for the ring-opening reactions of dihydropyrans with nucleophiles. Because these reactions proceeded with excellent atom-economy in a sustainable bio-based solvent, the present method was thus characterized by many properties of green chemistry, such as green solvent, atom-economy, and utilization of bio-based chemicals.