141846-57-3 Usage
Description
ALPHA-L-ERYTHRO-PENTOFURANOSYL CHLORIDE-2-DEOXY-BIS(4-METHYL BENZOATE), also known as 2-Deoxy-3,5-di-O-p-toluoyl-α-L-ribofuranosyl Chloride (CAS# 141846-57-3), is a white solid compound that is useful in organic synthesis. It is a derivative of ribose, a sugar molecule, with specific modifications that make it valuable for various applications in the chemical and pharmaceutical industries.
Uses
Used in Organic Synthesis:
ALPHA-L-ERYTHRO-PENTOFURANOSYL CHLORIDE-2-DEOXY-BIS(4-METHYL BENZOATE) is used as a synthetic intermediate for the development of various organic compounds. Its unique structure allows it to be a versatile building block in the synthesis of complex molecules, such as pharmaceuticals, agrochemicals, and other specialty chemicals.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, ALPHA-L-ERYTHRO-PENTOFURANOSYL CHLORIDE-2-DEOXY-BIS(4-METHYL BENZOATE) is used as a key component in the synthesis of novel drug candidates. Its chemical properties enable the development of new molecules with potential therapeutic applications, contributing to the advancement of drug discovery and innovation.
Used in Chemical Research:
ALPHA-L-ERYTHRO-PENTOFURANOSYL CHLORIDE-2-DEOXY-BIS(4-METHYL BENZOATE) is also used as a research tool in chemical laboratories. Its unique structure and reactivity make it an interesting subject for studying various chemical reactions and mechanisms, which can lead to a better understanding of organic chemistry and the development of new synthetic strategies.
Check Digit Verification of cas no
The CAS Registry Mumber 141846-57-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,4,1,8,4 and 6 respectively; the second part has 2 digits, 5 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 141846-57:
(8*1)+(7*4)+(6*1)+(5*8)+(4*4)+(3*6)+(2*5)+(1*7)=133
133 % 10 = 3
So 141846-57-3 is a valid CAS Registry Number.
InChI:InChI=1/C21H21ClO5/c1-13-3-7-15(8-4-13)20(23)25-12-18-17(11-19(22)26-18)27-21(24)16-9-5-14(2)6-10-16/h3-10,17-19H,11-12H2,1-2H3/t17?,18-,19+/m0/s1
141846-57-3Relevant articles and documents
Convenient preparation of 2-deoxy-3,5-di-O-p-toluoyl-α-D-erythro-pentofuranosyl chloride
Rolland, Valerie,Kotera, Mitsuharu,Lhomme, Jean
, p. 3505 - 3511 (1997)
By using acetyl chloride as HCl generator, the procedure for the Hoffer preparation of the α-chloro sugar 4a was significantly improved. The α-configuration of the chloro atom was confirmed by using NOE measurement. Sequential transformation of 4a to the β-anomer and to the furfuryl derivative 6 was studied.
Benzimidazole derivative BI292 as well as preparation method and application thereof
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Paragraph 0019; 0021-0024, (2021/06/09)
The invention discloses a benzimidazole derivative BI292 and a preparation method thereof, and the benzimidazole derivative BI292 is chemically named as 1-[(2R, 4S, 5R)-4-hydroxy-5-(hydroxymethyl) tetrahydrofuran-2-yl]-1H-benzo [d] imidazole-4-carboxylic acid methyl ester. The benzimidazole derivative and the pharmaceutically acceptable salt, the solvate and the hydrate of the benzimidazole derivative have excellent in-vivo and in-vitro anti-tumor activity on MCF-7, SK-BR-3, HCT 116, U-118 MG, U-87 MG and MDA-MB-468, and have a relatively good application prospect in preparation of anti-tumor drugs.
Development of a novel synthetic process for 2-deoxy-3,5-di-O-p-toluoyl- α-L-ribofuranosyl chloride: A versatile intermediate in the synthesis of 2′-deoxy-L-ribonucleosides
Chaudhuri, Narayan C.,Moussa, Adel,Stewart, Alistair,Wang, Jingyang,Storer, Richard
, p. 457 - 465 (2012/12/25)
A novel synthetic route to 2-deoxy-3,5-di-O-p-toluoyl-α-L- ribofuranosyl chloride (1) from inexpensive D-xylose (3) is described. 1 is a key intermediate in the synthesis of the antiviral agent 1-(2-deoxy-β-L- ribofuranosyl)thymine (β-L-thymidine) (2) and
