14189-19-6

Basic information

• Product Name: ethyl 4-methylbenzoyl carbonate
• Synonyms: ethyl 4-methylbenzoyl carbonate
• CAS NO: 14189-19-6
• Molecular Weight: 208.214
• Mol File: 14189-19-6.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: ethyl 4-methylbenzoyl carbonate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 4-methylbenzoyl carbonate(14189-19-6)
• EPA Substance Registry System: ethyl 4-methylbenzoyl carbonate(14189-19-6)

Safety Data

• Hazardous Substances Data: 14189-19-6(Hazardous Substances Data)

Upstream product

• 541-41-3 chloroformic acid ethyl ester 
• 99-94-5 p-Toluic acid 

Downstream Products

• 121902-42-9 2-p-Tolyl-1,3,6,9b-tetraaza-phenalene 
• 121902-34-9 2-p-Tolyl-1,3,6,9b-tetraaza-phenalene-4-carboxylic acid ethyl ester 
• 2653-44-3 ethenyl 4-methylbenzoate 
• 149834-12-8 S-4-methylbenzoyl coenzyme A 
• 22693-32-9 4-methylbenzoyl azide 
• 589-18-4 4-Methylbenzyl alcohol 
• 121902-12-3 9-Cyano-5-methyl-2-p-tolyl-1,9b-diaza-phenalene-7-carboxylic acid methyl ester 
• 121902-04-3 9-Cyano-2-p-tolyl-1,9b-diaza-phenalene-7-carboxylic acid methyl ester 
• 121902-23-6 5-Methyl-2-p-tolyl-1,9b-diaza-phenalene-7,9-dicarbonitrile 
• 121902-26-9 2-p-Tolyl-1,3,6,9b-tetraaza-phenalene-4-carbonitrile 
• 121902-19-0 2-p-Tolyl-1,9b-diaza-phenalene-7,9-dicarbonitrile 

Relevant articles and documents

Point mutations (Q19P and N23K) increase the operational solubility of a 2α-o-benzoyltransferase that conveys various acyl groups from CoA to a taxane acceptor

Two site-directed mutations within the wild-type 2-o-benzoyltransferase (tbf) cDNA, from Taxus cuspidata plants, yielded an encoded protein containing replacement amino acids at Q19P and N23K that map to a solvent-exposed loop region. The likely significant changes in the biophysical, properties invoked by these mutations caused the overexpressed, modified TBT (mTBT) to partition into the soluble enzyme fraction about 5-fold greater than the wild-type enzyme. Sufficient protein could now be acquired to examine the scope of the substrate specificity of mTBT by incubation with 7,13-O,O-diacetyl-2-Odebenzoylbaccatin III that was mixed individually with various substituted benzoyls, alkanoyls, and (E)-butenoyl CoA donors. The mTBT catalyzed the conversion of each 7,13-O,O-diacetyl-2-O-debenzoylbaccatin III to several 7,13-O,O-diacetyl-2O- acyl-2-O-debenzoylbaeeatin III analogues. The relative catalytic efficiency of mTBT with the 7,13-O,O-diacetyl-2-Odebenzoyl surrogate substrate and heterole carbonyl CoA substrates was slightly greater than with the natural aroyl substrate benzoyl CoA, while substituted benzoyl CoA thioesters were less productive. Short-chain hydrocarbon carbonyl and cyclohexanoyl CoA thioesters were also productive, where C4 substrates were transferred by mTBT with ～10- to 17-fold greater catalytic efficiency compared to the transfer of benzoyl. The described broad specificity of mTBT suggests that a plethora of 2-O-acyl variants of the antimitotic paclitaxel can be assembled through biocatalytic sequences.

Synthesis and biological activity of some novel N-aryl-nprime;-[5-(pyrid-4- yl)-1,3,4-thiadiazol-2-yl]ureas

With the aim of searching for biologically active urea compounds, a series of new N-aryl-N'-[5-(pyrid-4-yl)-1,3,4-thiadiazol-2-yl]ureas have been designed and synthesized. Their structures were confirmed by IR, 1H NMR, and elemental analysis. The crystal

Studies on Quinolizine Derivatives. XXII. Syntheses and Properties of 2-Phenylazacylazine Derivatives

By the reaction of 6-methyl-4-imino-4H-quinolizine derivatives (5, 8) with the mixed anhydrides (6a-h), 2-phenyl-1-azacylazines (7a-p, 9a-g) were obtained. 2-Phenyl-1,3,6-triazacyclazine derivatives (15a-h, 17a-h, 18a-g) were prepared by the