141892-41-3 Usage
Description
N-Fmoc-S-(4-methoxybenzyl)-L-cysteine, also known as Fmoc-Cys(pMeOBzl)-OH, is an amino acid building block derived from L-cysteine. It is characterized by its white powder form and is specifically modified with a 4-methoxybenzyl (pMeOBzl) group and an N-9-fluorenylmethoxycarbonyl (Fmoc) protecting group. N-Fmoc-S-(4-methoxybenzyl)-L-cysteine plays a crucial role in the field of peptide synthesis due to its unique structural features and reactivity.
Uses
Used in Pharmaceutical Industry:
N-Fmoc-S-(4-methoxybenzyl)-L-cysteine is used as a key building block for the synthesis of peptides and peptide-based drugs. Its application is essential for the development of novel therapeutics, as the growing peptide drug market demands fast and reliable peptide synthesis methods.
Used in Research and Development:
In the field of research and development, N-Fmoc-S-(4-methoxybenzyl)-L-cysteine serves as an important component in the design and synthesis of various peptide sequences. Its unique properties allow for the exploration of new peptide structures and functionalities, contributing to the advancement of scientific knowledge and potential applications in medicine and biotechnology.
Used in Drug Delivery Systems:
Similar to gallotannin, N-Fmoc-S-(4-methoxybenzyl)-L-cysteine can be utilized in the development of drug delivery systems. Its incorporation into peptide-based drug carriers can enhance the delivery, bioavailability, and therapeutic outcomes of peptide drugs, particularly in the context of cancer treatment and other diseases where peptide therapeutics are applicable.
Check Digit Verification of cas no
The CAS Registry Mumber 141892-41-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,4,1,8,9 and 2 respectively; the second part has 2 digits, 4 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 141892-41:
(8*1)+(7*4)+(6*1)+(5*8)+(4*9)+(3*2)+(2*4)+(1*1)=133
133 % 10 = 3
So 141892-41-3 is a valid CAS Registry Number.
InChI:InChI=1/C26H25NO5S/c1-31-18-12-10-17(11-13-18)15-33-16-24(25(28)29)27-26(30)32-14-23-21-8-4-2-6-19(21)20-7-3-5-9-22(20)23/h2-13,23-24H,14-16H2,1H3,(H,27,30)(H,28,29)/t24-/m0/s1
141892-41-3Relevant articles and documents
A comprehensive one-pot synthesis of protected cysteine and selenocysteine SPPS derivatives
Flemer, Stevenson
, p. 1257 - 1264 (2015/04/14)
A proof-of-principle methodology is presented in which all commercially-available cysteine (Cys) and selenocysteine (Sec) solid phase peptide synthesis (SPPS) derivatives are synthesized in high yield from easily prepared protected dichalcogenide precursors. A Zn-mediated biphasic reduction process applied to a series of four bis-Nα-protected dichalcogenide compounds allows facile conversion to their corresponding thiol and selenol intermediates followed by insitu S- or Se-alkylation with various electrophiles to directly access twenty one known Cys and Sec SPPS derivatives. Most of these derivatives were able to be precipitated in crude form out of petroleum ether in sufficient purity for direct use as peptide building blocks. Subsequent incorporation of these derivatives into peptide models nicely illustrates their viability and applicability toward SPPS.
