141944-00-5 Usage
Explanation
The molecular formula represents the number of atoms of each element present in a molecule of the compound.
Explanation
It belongs to a class of drugs called benzothiazepines, which are used for the treatment of various medical conditions.
Explanation
The compound has the potential to act as a calcium channel blocker, which can help relax blood vessels and improve blood flow.
Explanation
The benzothiazepine class of drugs, including this specific compound, is used for the treatment of conditions such as hypertension (high blood pressure) and angina (chest pain due to reduced blood flow to the heart).
Explanation
The compound's structural features make it of interest for further research and development in the pharmaceutical industry.
Explanation
The compound may also have potential applications in the treatment of cardiovascular and neurological disorders, due to its structural features and potential pharmaceutical properties.
Explanation
The molecular weight is the sum of the atomic weights of all the atoms in the molecule.
Explanation
This describes the specific arrangement of atoms and bonds in the molecule, which determines its chemical properties and potential pharmaceutical applications.
Explanation
The presence of a 4-fluorophenyl group in the molecule contributes to its unique properties and potential pharmaceutical applications.
Explanation
The solubility of the compound in various solvents is not provided in the material, but it is an important property for pharmaceutical development and drug delivery.
Class
Benzothiazepine derivative
Potential Pharmaceutical Applications
Calcium channel blocker
Medical Conditions Treated
Hypertension and angina
Structural Features
Interest for further research and development
Additional Treatment Potential
Cardiovascular and neurological disorders
Molecular Weight
341.38 g/mol (calculated from the molecular formula)
Chemical Structure
1,5-Benzothiazepin-4(5H)-one, 2-(4-fluorophenyl)-2,3-dihydro-
Fluorine Substitution
4-Fluorophenyl group
Solubility
Unknown (not provided in the material)
Check Digit Verification of cas no
The CAS Registry Mumber 141944-00-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,4,1,9,4 and 4 respectively; the second part has 2 digits, 0 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 141944-00:
(8*1)+(7*4)+(6*1)+(5*9)+(4*4)+(3*4)+(2*0)+(1*0)=115
115 % 10 = 5
So 141944-00-5 is a valid CAS Registry Number.
141944-00-5Relevant articles and documents
Discovery of Novel Benzothiazepinones as Irreversible Covalent Glycogen Synthase Kinase 3β Inhibitors for the Treatment of Acute Promyelocytic Leukemia
Zhang, Peng,Min, Zhihui,Gao, Yang,Bian, Jiang,Lin, Xin,He, Jie,Ye, Deyong,Li, Yilin,Peng, Chao,Cheng, Yunfeng,Chu, Yong
, p. 7341 - 7358 (2021/06/28)
Recently, irreversible inhibitors have attracted great interest in antitumors due to their advantages of forming covalent bonds to target proteins. Herein, some benzothiazepinone compounds (BTZs) have been designed and synthesized as novel covalent GSK-3β inhibitors with high selectivity for the kinase panel. The irreversible covalent binding mode was identified by kinetics and mass spectrometry, and the main labeled residue was confirmed to be the unique Cys14 that exists only in GSK-3β. The candidate 4-3 (IC50 = 6.6 μM) showed good proliferation inhibition and apoptosis-inducing ability to leukemia cell lines, low cytotoxicity on normal cell lines, and no hERG inhibition, which hinted the potential efficacy and safety. Furthermore, 4-3 exhibited decent pharmacokinetic properties in vivo and remarkably inhibited tumor growth in the acute promyelocytic leukemia (APL) mouse model. All the results suggest that these newly irreversible BTZ compounds might be useful in the treatment of cancer such as APL.
An efficient one-pot procedure for the synthesis of 1,5-benzothiazepinones catalyzed by tetrabutylammonium fluoride (TBAF)
Zhang, Peng,Ye, Deyong,Chu, Yong
supporting information, p. 3743 - 3745 (2016/07/26)
A practical and efficient method for the preparation of 1,5-benzothiazepinone derivatives in good yields has been developed using tetrabutylammonium fluoride (TBAF) as a catalyst. This study not only expands the previous work on the substrate scope and al
Benzodiazepine Analogues. Part 10. Conformational Analysis of Benzoxazepinone, Benzodiazepinone and Benzothiazepinone Derivatives
English, Robin B.,Kaye, Perry T.,Mphahlele, M. Jack,Whittal, Rory D.
, p. 2319 - 2336 (2007/10/03)
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