1419609-94-1

Basic information

• Product Name: 1-(((5S,7S)-3-(5-(2-hydroxypropan-2-yl)pyrazin-2-yl)-7-methyl-2-oxo-1-oxa-3-azaspiro[4.5]decan-7-yl)methyl)-1H- benzo[d]imidazole-6-carbonitrile
• CAS NO: 1419609-94-1
• Molecular Weight: 460.536
• Mol File: 1419609-94-1.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 682.1±65.0 °C(Predicted)
• Density: 1.35±0.1 g/cm3(Predicted)
• CAS DataBase Reference: 1-(((5S,7S)-3-(5-(2-hydroxypropan-2-yl)pyrazin-2-yl)-7-methyl-2-oxo-1-oxa-3-azaspiro[4.5]decan-7-yl)methyl)-1H- benzo[d]imidazole-6-carbonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(((5S,7S)-3-(5-(2-hydroxypropan-2-yl)pyrazin-2-yl)-7-methyl-2-oxo-1-oxa-3-azaspiro[4.5]decan-7-yl)methyl)-1H- benzo[d]imidazole-6-carbonitrile(1419609-94-1)
• EPA Substance Registry System: 1-(((5S,7S)-3-(5-(2-hydroxypropan-2-yl)pyrazin-2-yl)-7-methyl-2-oxo-1-oxa-3-azaspiro[4.5]decan-7-yl)methyl)-1H- benzo[d]imidazole-6-carbonitrile(1419609-94-1)

Safety Data

• Hazardous Substances Data: 1419609-94-1(Hazardous Substances Data)

Usage

Description

1-(((5S,7S)-3-(5-(2-hydroxypropan-2-yl)pyrazin-2-yl)-7-methyl-2-oxo-1-oxa-3-azaspiro[4.5]decan-7-yl)methyl)-1H-benzo[d]imidazole-6-carbonitrile is a complex heterocyclic compound with a unique structure, featuring a spirodecane moiety, a benzoimidazole ring connected to a carbonitrile group, and a pyrazine ring with a hydroxypropan-2-yl substitution. Its stereochemistry is defined by the (5S,7S) configuration, which may indicate potential medicinal or biochemical applications. Further research is required to explore its properties and possible uses.

Uses

1. Used in Pharmaceutical Applications:
1-(((5S,7S)-3-(5-(2-hydroxypropan-2-yl)pyrazin-2-yl)-7-methyl-2-oxo-1-oxa-3-azaspiro[4.5]decan-7-yl)methyl)-1H-benzo[d]imidazole-6-carbonitrile is used as a potential pharmaceutical candidate for various applications due to its diverse and unique structure, which may offer novel interactions with biological targets.
2. Used in Chemical Research:
1-(((5S,7S)-3-(5-(2-hydroxypropan-2-yl)pyrazin-2-yl)-7-methyl-2-oxo-1-oxa-3-azaspiro[4.5]decan-7-yl)methyl)-1Hbenzo[d]imidazole-6-carbonitrile is used as a subject of study in chemical research to understand its properties, reactivity, and potential applications in the synthesis of other complex molecules or materials.
3. Used in Material Science:
The unique structure of 1-(((5S,7S)-3-(5-(2-hydroxypropan-2-yl)pyrazin-2-yl)-7-methyl-2-oxo-1-oxa-3-azaspiro[4.5]decan-7-yl)methyl)-1H-benzo[d]imidazole-6-carbonitrile may have potential applications in material science, particularly in the development of new materials with specific properties or functions.

Upstream product

• 1416324-27-0 (2R,3R,7S)-7-(bromomethyl)-7-methyl-2,3-diphenyl-1,4-dioxaspiro[4.5]decane 
• 1416324-28-1 {[(2R,3R,7S)-7-methyl-2,3-diphenyl-1,4-dioxaspiro[4.5]dec-7-yl]methyl}amine 
• 1416324-29-2 3-({[(2R,3R,7S)-7-methyl-2,3-diphenyl-1,4-dioxaspiro[4,5]dec-7-yl]methyl}amino)-4-nitrobenzonitrile 
• 1416324-30-5 1-{[(2R,3R,7S)-7-methyl-2,3-diphenyl-1,4-dioxaspiro[4,5]dec-7-yl]methyl}-1H-benzimidazole-6-carbonitrile 
• 1416324-31-6 1-{[(1S)-1-methyl-3-oxocyclohexaneyl]methyl}-1H-benzimidazole-6-carbonitrile 
• 1416324-68-9 1-{[(3S,5S)-5-methyl-1-oxaspiro[2.5]oct-5-yl]methyl}-1H-benzimidazole-6-carbonitrile 
• 1303967-23-8 2-(5-bromopyrazin-2-yl)propan-2-ol 
• 1419610-42-6 1-{[(5S,7S)-7-methyl-2-oxo-1-oxa-3-azaspiro[4.5]dec-7-yl]methyl}-1H-benzimidazole-6-carbonitrile 
• 210037-58-4 5-bromopyrazine-2-carboxylic acid methyl ester 
• 1416324-69-0 1-{[(3R,5S)-5-methyl-1-oxaspiro[2.5]oct-5-yl]methyl}-1H-benzimidazole-6-carbonitrile 
• 1240596-83-1 2-(5-chloropyrazin-2-yl)propan-2-ol 
• 33332-25-1 methyl 5-chloropyrazine-2-carboxylate 
• 1416324-71-4 1-{[(3S,5S)-3-hydroxy-3-(hydroxymethyl)-1-methylcyclohexaneyl]methyl}-1H-benzimidazole-6-carbonitrile 
• 1419610-43-7 1-(((5S,7S)-3-(4-methoxybenzyl)-7-methyl-2-oxo-1-oxa-3-azaspiro[4.5]decan-7-yl)methyl)-1H-benzo[d]imidazole-6-carbonitrile 

Relevant articles and documents

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GSK2798745, a clinical candidate, was identified as an inhibitor of the transient receptor potential vanilloid 4 (TRPV4) ion channel for the treatment of pulmonary edema associated with congestive heart failure. We discuss the lead optimization of this novel spirocarbamate series and specifically focus on our strategies and solutions for achieving desirable potency, rat pharmacokinetics, and physicochemical properties. We highlight the use of conformational bias to deliver potency and optimization of volume of distribution and unbound clearance to enable desirable in vivo mean residence times.