1420-49-1 Usage
Description
Androsta-3,5-diene-7,17-dione is a synthetic steroidal compound that serves as an important intermediate in the pharmaceutical industry. It is characterized by its unique molecular structure, which features a steroidal core with double bonds at the 3 and 5 positions, and a ketone group at the 7 and 17 positions. Androsta-3,5-diene-7,17-dione is known for its versatile applications in various fields, including medicine, pharmaceuticals, and chemical synthesis.
Uses
Used in Pharmaceutical Industry:
Androsta-3,5-diene-7,17-dione is used as an intermediate in the synthesis of various steroidal drugs, including anabolic steroids and corticosteroids. Its unique structure allows for the development of potent and effective medications that can be used to treat a wide range of medical conditions, such as inflammation, muscle wasting, and hormonal imbalances.
Used in Aromatase Inhibition:
Androsta-3,5-diene-7,17-dione is used as an aromatase inhibitor, which helps in the reduction of estrogen production. This application is particularly useful in the treatment of conditions where estrogen levels need to be controlled, such as hormone-related cancers or gynecomastia.
Used in Synthesis of Anti-Cancer Agents:
Androsta-3,5-diene-7,17-dione serves as a potential reagent in the synthesis of anti-cancer agents, such as MGC-803. Its involvement in the development of these agents highlights its importance in the fight against cancer and its potential to contribute to the discovery of novel therapeutic approaches.
Check Digit Verification of cas no
The CAS Registry Mumber 1420-49-1 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 1,4,2 and 0 respectively; the second part has 2 digits, 4 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 1420-49:
(6*1)+(5*4)+(4*2)+(3*0)+(2*4)+(1*9)=51
51 % 10 = 1
So 1420-49-1 is a valid CAS Registry Number.
InChI:InChI=1/C19H24O2/c1-18-9-4-3-5-12(18)11-15(20)17-13-6-7-16(21)19(13,2)10-8-14(17)18/h3,5,11,13-14,17H,4,6-10H2,1-2H3/t13-,14-,17-,18-,19-/m0/s1
1420-49-1Relevant articles and documents
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Billeter,Miescher
, p. 629,632 (1948)
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Ergosteroids VII: perchloric acid-induced transformations of 7-oxygenated steroids and their bio-analytical applications--a liquid chromatographic-mass spectrometric study.
Marwah, Ashok,Marwah, Padma,Lardy, Henry
, p. 233 - 248 (2002)
Sulfate esters of 7-oxo-delta(5)-steroids can be selectively and quantitatively hydrolyzed to the corresponding free steroids in the presence of carboxylic acid esters by solvolysis with perchloric acid in ethyl acetate at room temperature. Sulfates as well as carboxylic acid esters, methyl ethers, and ketals can be quantitatively converted to the corresponding 3,5-diene-7-one derivatives by heating with perchloric acid in methanol at 65 degrees C. The dienes have a strong UV absorption with maximum centered around 284 nm. These reactions have been used for the characterization and structural elucidation of 7-oxygenated-delta(5)-steroids that are present in complex biomatrices and can also be used for the quantitative estimation of total 7-oxo-delta(5)-steroids (free as well as conjugated) in biological matrices.
Synthesis and Elucidation of Structure of Deuterated Androsta-3,5-diene-7,17-dione
Abzianidze,Panikorovskii,Chisty,Kochura,Krivorotov,Kuznetsov,Radilov
, (2017)
The title compound was synthesized as an internal standard for the quantitative determination of Arimistane in biological samples. [2H7] Arimistane was obtained from Arimistane-d0 by alkaline H/2H exchange of th