142009-99-2

Basic information

• Product Name: 4-Benzylaminocyclohexanone
• Synonyms: 4-BENZYLAMINOCYCLOHEXANONE;4-(BENZYLAMINO)CYCLOHEXANONE HCL;-benzylaminocyclohexanone;N-Benzyl-4-amino-cyclohexanone;4-(benzylaMino)cyclohexan-1-one;Cyclohexanone,4-[(phenylMethyl)aMino]-;4-[(Phenylmethyl)amino]cyclohexanone
• CAS NO: 142009-99-2
• Molecular Formula: C₁₃H₁₇NO
• Molecular Weight: 203.28
• Mol File: 142009-99-2.mol
• Article Data: 11

Chemical Properties

• Boiling Point: 337.539 °C at 760 mmHg
• Flash Point: 132.544 °C
• Appearance: /
• Density: 1.06 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.548
• Storage Temp.: 2-8°C
• PKA: 8.97±0.20(Predicted)
• CAS DataBase Reference: 4-Benzylaminocyclohexanone(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Benzylaminocyclohexanone(142009-99-2)
• EPA Substance Registry System: 4-Benzylaminocyclohexanone(142009-99-2)

Safety Data

• Hazardous Substances Data: 142009-99-2(Hazardous Substances Data)

Usage

General Description

4-Benzylaminocyclohexanone is a chemical compound that consists of a cyclohexanone ring with a benzylamine group attached to the carbon 4 position. It is used in organic synthesis as a building block for creating various pharmaceuticals, agrochemicals, and dyes. The benzylamine group provides the compound with nucleophilic properties, making it useful for such applications. This chemical is also known for its potential as a precursor for the synthesis of diverse bioactive compounds. Additionally, its unique structure and properties make it an interesting target for researchers studying organic chemistry and drug discovery.

InChI:InChI=1/C13H17NO/c15-13-8-6-12(7-9-13)14-10-11-4-2-1-3-5-11/h1-5,12,14H,6-10H2

Upstream product

• 3287-99-8 benzylamine hydrochloride 
• 100-46-9 benzylamine 
• 248585-29-7 trans-4-(benzylidene-amino)-cyclohexanol 
• 100-52-7 benzaldehyde 
• 162338-03-6 N-benzyl-trans-4-aminocyclohexanol 
• 27489-62-9 trans-4-hydroxycyclohexylamine 
• 4746-97-8 cyclohexanedione monoethylene ketal 
• 230287-23-7 N-(1,4-dioxaspiro[4.5]decyl-7-idene)benzylamine 
• 131511-13-2 4-(N-benzylamino)cyclohexanone ethylene acetal 

Downstream Products

• 192373-28-7 1-Amino-4-(benzyl-tert-butoxycarbonyl-amino)-cyclohexanecarboxylic acid 
• 192373-17-4 8-(Benzyl-tert-butoxycarbonyl-amino)-2,4-dioxo-1,3-diaza-spiro[4.5]decane-1,3-dicarboxylic acid di-tert-butyl ester 
• 1357922-30-5 4-(benzylamino)-1-hydroxycyclohexanecarbonitrile 
• 162338-03-6 N-benzyl-trans-4-aminocyclohexanol 

Relevant articles and documents

3-(dimethylaminomethyl) cyclohex-4-alcohol derivative as well as preparation method and pharmaceutical application thereof

The invention belongs to the field of pharmacy, and relates to a 3-(dimethylaminomethyl) cyclohex-4-alcohol derivative with a general formula (I) or a salt thereof and a preparation method, and relates to an application of the compound in treatment of opioid receptor mediated diseases. The present invention provides a pharmaceutically acceptable solvate or hydrate of a compound of formula (I), and also provides a pharmaceutical composition comprising: a compound of formula (I) or a pharmaceutically acceptable salt, solvate or hydrate thereof; and a pharmaceutically acceptable carrier. The medicine prepared from the compound can be used for treating or improving diseases related to an opioid receptor; wherein the diseases can be selected from but not limited to pain, gastrointestinal diseases and depression.

Synthesis of the tetracyclic ABCD ring systems of madangamines D-F

Synthesis of the tetracyclic cores of madangamines D-F was achieved, featuring a reductive radical process from an ethoxycarbonyldichloroacetamide to build the morphan nucleus, a Mitsunobu-type aminocyclization toward the common diazatricyclic intermediate, and ring-closing metathesis reactions for the macrocyclization step leading to the 13- to 15-membered rings.

BENZIMIDAZOLE AND AZABENZIMIDAZOLE COMPOUNDS THAT INHIBIT ANAPLASTIC LYMPHOMA KINASE

Compounds of Formula (I) are useful inhibitors of anaplastic lymphoma kinase. Compounds of Formula (I) have the following structure: where the definitions of the variables are provided herein.