142012-38-2Relevant articles and documents
LiBr-catalyzed one-pot three-component domino strategy toward the construction of β-phosphonomalonates scaffolds in aqueous conditions
Kumar, Vikas,Kour, Parteek,Kumar, Anil
, p. 607 - 613 (2019/12/30)
LiBr-mediated domino Knoevenagel-phospha-Michael strategy has been established for the synthesis of β-phosphonomalonates under aqueous conditions. It is noteworthy that the developed protocol is effective with a wide range of aldehydes to deliver a diverse range of β-phosphonomalonates in good to excellent yields. The mild reaction conditions, easier procedure, use of aqueous media, inexpensive and water tolerant property of LiBr are important advantages of this protocol.
Aqueous microwave-assisted DMAP catalyzed synthesis of β-phosphonomalonates and 2-amino-4H-chromen-4-ylphosphonates via a domino Knoevenagel-phospha-Michael reaction
Kour, Parteek,Kumar, Anil,Rai, Vijai K.
, p. 140 - 145 (2017/01/22)
An aqueous microwave (mw)-assisted DMAP catalyzed one-pot highly efficient route to synthesize β-phosphonomalonates and 2-amino-4H-chromen-4-yl phosphonates has been demonstrated via the domino Knoevenagel-phospha-Michael reaction of aryl aldehyde/salicylaldehyde, malononitrile/ethyl cyanoacetate and alkyl phosphite ester. Optimization of reaction conditions were performed by using conventional and microwave synthetic approaches. This conversion proceeded smoothly to deliver the desired product in good to excellent yields (75–95%) in a short reaction time (10–12?min). The present methodology is very simple, environmentally benign, high yielding and has very well demonstrated the synergistic effect of water and microwaves.
A quaternary ammonium salt [H-dabco][AcO]: As a recyclable and highly efficient catalyst for the one-pot synthesis of β-phosphonomalonates
Yu, Ya-Qin,Xu, Da-Zhen
, p. 28857 - 28863 (2015/04/14)
A simple, green and highly efficient approach for the one-pot three-component synthesis of β-phosphonomalonates has been developed. In the presence of the quaternary ammonium salt catalysts, the β-phosphonomalonates were obtained in excellent yields within short times via tandem Knoevenagel-phospha-Michael reaction. The reaction of aldehydes/ketones, active methylene compounds, and diethyl phosphite performed at room temperature under solvent-free conditions. No column purification is required and the products can be purified by simple crystallization. The catalysts can be easily recovered and reused several times without significant activity loss. This journal is
