142012-65-5 Usage
Description
4-(Trifluoromethyl)-DL-phenylglycine, also known as α-Amino-4-(Trifluoromethyl)benzeneacetic Acid, is a chemical compound derived from 4-(Trifluoromethyl)benzeneacetic Acid (T792090). It is characterized by the presence of a trifluoromethyl group and an amino group attached to a phenylglycine structure. 4-(Trifluoromethyl)-DL-phenylglycine serves as an important intermediate in the synthesis of various pharmaceutical agents and has potential applications in the development of new drugs.
Uses
Used in Pharmaceutical Industry:
4-(Trifluoromethyl)-DL-phenylglycine is used as an intermediate for the synthesis of PPARγ/δ dual agonists. These agonists are significant in the development of treatments for metabolic disorders, such as diabetes and obesity, due to their role in regulating cellular differentiation and energy homeostasis.
Additionally, 4-(Trifluoromethyl)-DL-phenylglycine is used in preparing heterocyclic xanthine derivatives, which are highly potent and selective human A2B adenosine receptor antagonists. These antagonists have potential therapeutic applications in treating various conditions, including asthma, chronic obstructive pulmonary disease (COPD), and other inflammatory diseases.
Check Digit Verification of cas no
The CAS Registry Mumber 142012-65-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,4,2,0,1 and 2 respectively; the second part has 2 digits, 6 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 142012-65:
(8*1)+(7*4)+(6*2)+(5*0)+(4*1)+(3*2)+(2*6)+(1*5)=75
75 % 10 = 5
So 142012-65-5 is a valid CAS Registry Number.
InChI:InChI=1/C9H8F3NO2/c10-9(11,12)6-3-1-5(2-4-6)7(13)8(14)15/h1-4,7H,13H2,(H,14,15)
142012-65-5Relevant articles and documents
CATALYST COMPOUNDS
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Paragraph 0314; 0324, (2015/03/28)
The present invention relates to an iridium-based catalyst compound for hydrogenating reducible moieties, especially imines and iminiums, the catalyst compounds being defined by the formulas: where ring B is either itself polycyclic, or ring B together with R is polycyclic. The catalysts of the invention are particularly effective in reductive amination procedures 10 which involve the in situ generation of the imine or iminium under reductive hydrogenative conditions.
CATALYST COMPOUNDS
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Paragraph 00163; 00173, (2013/11/05)
The present invention relates to an iridium-based catalyst compound for hydrogenating reducible moieties, especially imines and iminiums, the catalyst compounds being defined by the formulas: where ring B is either itself polycyclic, or ring B together with R is polycyclic. The catalysts of the invention are particularly effective in reductive amination procedures 10 which involve the in situ generation of the imine or iminium under reductive hydrogenative conditions.