14202-27-8Relevant articles and documents
Stereoselective synthesis of alkenylated malonic diamide using masked acyl cyanide
Nemoto,Ibaragi,Bando,Kido,Shibuya
, p. 1319 - 1322 (2007/10/03)
A highly stereoselective synthesis of an alkenylated malonic diamide starting from a γ,δ-epoxy-α,β-unsaturated carboxamide was accomplished using the masked acyl cyanide (MAC: the protected hydroxymalonitrile) via palladium-catalyzed regio- and stereoselective carbon-carbon bond formation.
A facile chemoenzymatic route to optically active 4,5-disubstituted-2E-hexenoate derivastives. II
Akita,Umezawa,Takano,Oishi
, p. 680 - 684 (2007/10/02)
The reaction of (±) methyl 4,5-trans-epoxy-(2E)-hexenoate (1) with nucleophiles having heteroatoms in the presence of BF3 · Et2O gave the 4,5-anti-5-hydroxy-4- and/or 2,5-anti-5-hydroxy-2-substituted products. Among them, the (±)-4,5