142073-93-6

Basic information

• Product Name: 2-(4-methylphenyl)-6-chloroimidazolo[1,2-a]pyridine
• Synonyms: 2-(4-methylphenyl)-6-chloroimidazolo[1,2-a]pyridine
• CAS NO: 142073-93-6
• Molecular Formula: C₁₄H₁₁ClN₂
• Molecular Weight: 243
• Mol File: 142073-93-6.mol
• Article Data: 8

Chemical Properties

• Melting Point: 223-224 °C
• Appearance: /
• Density: 1.23±0.1 g/cm3(Predicted)
• PKA: 5.15±0.50(Predicted)
• CAS DataBase Reference: 2-(4-methylphenyl)-6-chloroimidazolo[1,2-a]pyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-methylphenyl)-6-chloroimidazolo[1,2-a]pyridine(142073-93-6)
• EPA Substance Registry System: 2-(4-methylphenyl)-6-chloroimidazolo[1,2-a]pyridine(142073-93-6)

Safety Data

• Hazardous Substances Data: 142073-93-6(Hazardous Substances Data)

Usage

Class of organic compounds

Phenylpyridines 2-(4-methylphenyl)-6-chloroimidazolo[1,2-a]pyridine belongs to the phenylpyridines class, which are heterocyclic aromatic compounds containing a pyridine ring.

Pyridine ring substitution

4-position with a phenyl group The pyridine ring in this compound is substituted at the 4th position with a phenyl group, which influences its chemical properties and potential applications.

Imidazo[1,2-a]pyridine derivative

Known for potential biological activities This compound is an imidazo[1,2-a]pyridine derivative, a class of compounds known for their potential biological activities and therapeutic applications.

Pharmaceutical importance

Anti-inflammatory, anti-fungal, and anti-cancer properties 2-(4-methylphenyl)-6-chloroimidazolo[1,2-a]pyridine is being studied for its potential as a drug candidate due to its significant pharmaceutical importance, particularly for its anti-inflammatory, anti-fungal, and anti-cancer properties.

Upstream product

• 2089-33-0 4-methylacethophenone oxime 
• 1072-98-6 5-chloro-2-pyridylamine 
• 96475-75-1 4‐methylacetophenone oxime acetate 
• 122-00-9 para-methylacetophenone 
• 40805-62-7 2-iodo-1-(4-methylphenyl)ethanone 
• 54187-96-1 1-(chloromethyl)-1H-benzotriazole 
• 104-87-0 4-methyl-benzaldehyde 
• 619-41-0 4-(bromoacetyl)toluene 

Downstream Products

• 365213-35-0 [6-chloro-2-p-tolylimidazo[1,2-a]pyridin-3-ylmethyl]-dimethylamine 
• 1310492-84-2 6-chloro-3-(phenylthio)-2-(4-methylphenyl)imidazo[1,2-a]pyridine 
• 365213-54-3 2-(6-chloro-2-p-tolyl-imidazo[1,2-a]pyridin-3-yl)-acetamide 
• 365213-63-4 (6-chloro-2-p-tolyl-imidazo[1,2-a]pyridin-3-yl)-acetic acid 
• 82626-23-1 2-(6-Chloro-2-p-tolyl-imidazo[1,2-a]pyridin-3-yl)-N,N-dimethyl-acetamide 
• 142073-94-7 3-benzamidomethyl-6-chloro-2-(4'-tolyl)imidazo<1,2-a>pyridine 

Relevant articles and documents

Efficient syntheses of imidazolo[1,2-αa]pyridines and -[2,1-α]isoquinolines

2-Aminopyridines 1a-c and 1-aminoisoquinoline with 1-chloromethylbenzotriazole give 2-amino-1-[α-benzotriazol-1-ylmethyl]pyridinium chlorides 2a-c and 1-amino-2-(α-benzotriazol-1-ylmethyl)-isoquinolinium chloride 12, respectively. Compounds 2a-c and 12 react with aryl aldehydes 3a-h to afford imidazolo[1,2-α]pyridines 7a-k and imidazolo[2,1-α]isoquinolines 13a,b in good yields.

Green procedure for highly efficient, rapid synthesis of imidazo[1,2-a]pyridine and its late stage functionalization

We unfold a rapid synthetic protocol for the preparation of imidazo[1,2-a]pyridine in cyclohexane. This methodology includes several advantages like shorter reaction time, catalyst free, broader substrate scope, and good yields of the desired products. La

Synthesis and antimicrobial activity of novel imidazo[1,2-a]pyridinopyrimidine-2,4,6(1H,3H,5H)-triones and thioxopyrimidine-4,6(1H,5H)diones

A novel series of imidazo[1,2-a]pyridinopyrimidine-2,4,6(1H,3H,5H)-triones and thioxopyrimidine-4,6(1H,5H)diones were synthesized via multistep synthesis starting from 2-aminopyridine on cyclisation with phenacyl bromide followed by Vilsmeier-Haack and Kn