1420800-30-1Relevant articles and documents
CHEMICAL COMPOUNDS
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, (2022/01/23)
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3-BENZOYL-1H-PYRROLO[2,3-B]PYRIDINE DERIVATIVES AS MKK4 INHIBITORS FOR TREATING LIVER DISEASES
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Page/Page column 16-17, (2021/07/24)
The invention relates to compounds of formula (I) which are inhibitors of MKK4 (mitogen-activated protein kinase kinase 4) and their use in promoting liver regeneration or reducing or preventing hepatocyte death. The compounds selectively inhibit protein
Aniline WDR5 protein-protein interaction inhibitor as well as preparation method and application thereof
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Paragraph 0279-0283, (2019/05/22)
The invention discloses a WDR5 protein-protein interaction inhibitor. The WDR5 protein-protein interaction inhibitor comprises a compound with a structure shown as a general formula (I). Experiments show that the inhibitor acts on WDR5 protein and interacting proteins thereof including but not limited to MLL, selectively inhibits the proliferation of leukemia cells, inhibits the methylation of H3K4 and the expression of downstream Hox/Meis-1 at the cell level. The invention also discloses a preparation method of the inhibitor as well as an application in preparing drugs for treating acute leukemia and other related diseases. (Shown in the description).