1421356-77-5

Basic information

• Product Name: N-(3-chloro-4-fluorophenyl)-6-(5-(((2-(4-nitrophenyl)ethyl)amino)methyl)-2-furyl)-4-quinazolinamine
• Synonyms: N-(3-chloro-4-fluorophenyl)-6-(5-(((2-(4-nitrophenyl)ethyl)amino)methyl)-2-furyl)-4-quinazolinamine
• CAS NO: 1421356-77-5
• Molecular Weight: 517.947
• Mol File: 1421356-77-5.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: N-(3-chloro-4-fluorophenyl)-6-(5-(((2-(4-nitrophenyl)ethyl)amino)methyl)-2-furyl)-4-quinazolinamine(CAS DataBase Reference)
• NIST Chemistry Reference: N-(3-chloro-4-fluorophenyl)-6-(5-(((2-(4-nitrophenyl)ethyl)amino)methyl)-2-furyl)-4-quinazolinamine(1421356-77-5)
• EPA Substance Registry System: N-(3-chloro-4-fluorophenyl)-6-(5-(((2-(4-nitrophenyl)ethyl)amino)methyl)-2-furyl)-4-quinazolinamine(1421356-77-5)

Safety Data

• Hazardous Substances Data: 1421356-77-5(Hazardous Substances Data)

Upstream product

• 1421356-86-6 N-(3-chloro-4-fluorophenyl)-6-(5-formyl-2-furyl)-4-quinazolinamine 
• 29968-78-3 2-(4-nitrophenyl)ethylamine monohydrochloride 
• 578737-95-8 N-(3-chloro-4-fluorophenyl)-6-iodo-4-quinazolinamine 

Relevant articles and documents

QUINAZOLINE DERIVATIVE, COMPOSITION HAVING THE DERIVATIVE, AND USE OF THE DERIVATIVE IN PREPARING MEDICAMENT

A class of quinazoline derivatives or pharmaceutically acceptable salts or solvates thereof with novel structures is provided; meanwhile, a pharmaceutical composition comprising a pharmaceutically effective amount of said quinazoline derivatives or pharmaceutically acceptable salts or solvates thereof, and pharmaceutically acceptable excipients or additives is also provided. By modifying and transforming the quinazoline and screening of the transformed compounds on the activity of tyrosine kinase inhibition, most of the compounds have been found to possess inhibitory activity against one or several of EGFR, VEGFR-2, c-erbB-2, c-erbB-4, c-met, tie-2, PDGFR, c-src, lck, Zap70 and fyn kinases. The present invention has the advantages of reasonable design, broad source of and easy access to the raw materials, simple and easy operation of the preparation methods, mild reaction conditions, high yield of the products and being beneficial for industrial-scale production.