142141-37-5

Basic information

• Product Name: 2-AMINO-N-CYCLOPENTYLBENZAMIDE
• CAS NO: 142141-37-5
• Molecular Formula: C₁₂H₁₆N₂O
• Molecular Weight: 204.27
• Mol File: 142141-37-5.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 410°C at 760 mmHg
• Flash Point: 201.7°C
• Appearance: /
• Density: 1.14g/cm³
• Vapor Pressure: 6.24E-07mmHg at 25°C
• Refractive Index: 1.584
• CAS DataBase Reference: 2-AMINO-N-CYCLOPENTYLBENZAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-AMINO-N-CYCLOPENTYLBENZAMIDE(142141-37-5)
• EPA Substance Registry System: 2-AMINO-N-CYCLOPENTYLBENZAMIDE(142141-37-5)

Safety Data

• Hazardous Substances Data: 142141-37-5(Hazardous Substances Data)

Usage

Classification

Organic compound, benzene and substituted derivatives

Derivative of

Benzoic acid

Contains

Cyclopentylamine group

Uses

Active ingredient in synthesis of drugs and pharmaceuticals

Potential therapeutic effects

Treatment of psychiatric and neurological disorders

Being studied for

Antipsychotic and anticonvulsant properties

Additional potential uses

Analgesic and anti-inflammatory agent

InChI:InChI=1/C12H16N2O/c13-11-8-4-3-7-10(11)12(15)14-9-5-1-2-6-9/h3-4,7-9H,1-2,5-6,13H2,(H,14,15)

Upstream product

• 118-48-9 isatoic anhydride 
• 1003-03-8 Cyclopentamine 

Downstream Products

• 1448791-14-7 2-(4-chloro-6-(3,4,5-trimethoxyphenylamino)-1,3,5-triazin-2-ylamino)-N-cyclopentylbenzamide 
• 142141-41-1 N-(o-aminobenzyl)cyclopentylamine 

Relevant articles and documents

Palladium-catalyzed atroposelective coupling-cyclization of 2-isocyanobenzamides to construct axially chiral 2-aryl- And 2,3-diarylquinazolinones

A palladium-catalyzed imidoylative cycloamidation of N-alkyl-2-isocyanobenzamides with 2,6-disubstituted aryl iodides, affording unprecedented axially chiral 2-arylquinazolinones, has been developed with good yields and atroposelectivities. In this coupling-cyclization process, the biaryl linkage and the heteroaromatic ring are formed sequentially in one step. When N-(2,4dimethoxyphenyl)-2-isocyanobenzamide is applied as a substrate, 2,3-diarylquinazolinones containing two stereogenic axes are produced with moderate diastereoselectivity and good enantioselectivities.

Synthesis and anticancer activity of N -substituted 2-arylquinazolinones bearing trans -stilbene scaffold

A novel series of 2-arylquinazolinones 7a-o bearing trans-stilbene moiety were designed, synthesized, and evaluated against human breast cancer cell lines including human breast adenocarcinoma (MCF-7 and MDA-MB-231) and human ductal breast epithelial tumor (T-47D). Among the tested compounds, the sec-butyl derivative 7h showed the best profile of activity (IC50 5 μM) against all cell lines, being 2-fold more potent than standard drug, etoposide. Our investigation revealed that the cytotoxic activity was significantly affected by N3-alkyl substituents. Furthermore, the morphological analysis by acridine orange/ethidium bromide double staining test and flow cytometry analysis indicated that the prototype compound 7h can induce apoptosis in MCF-7 and MDA-MB-231 cells.

BENZIMIDAZOLE DERIVATIVES AND THEIR USE AS ANTIVARAL AGENTS

The invention provides compounds of formula (I) wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11 and R12 are as defined in the specification, and optical isomers, racemates and tautomers thereof, and pharmaceutically acceptable salts thereof; together