1421429-90-4

Basic information

• Product Name: N-(diphenylmethylene)-isoquinolin-4-amine
• Synonyms: N-(diphenylmethylene)-isoquinolin-4-amine
• CAS NO: 1421429-90-4
• Molecular Weight: 308.382
• Mol File: 1421429-90-4.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: N-(diphenylmethylene)-isoquinolin-4-amine(CAS DataBase Reference)
• NIST Chemistry Reference: N-(diphenylmethylene)-isoquinolin-4-amine(1421429-90-4)
• EPA Substance Registry System: N-(diphenylmethylene)-isoquinolin-4-amine(1421429-90-4)

Safety Data

• Hazardous Substances Data: 1421429-90-4(Hazardous Substances Data)

Upstream product

• 1013-88-3 Benzophenone imine 
• 1532-97-4 4-bromoisoquinoline 

Downstream Products

• 1421428-70-7 1-((2-(cyclohexylthio)-6-(trifluoromethyl)pyridin-3-yl)methyl)-3-(isoquinolin-4-yl)urea 
• 1229383-55-4 phenyl isoquinolin-4-ylcarbamate 
• 23687-25-4 4-aminoisoquinoline 

Relevant articles and documents

6,6-Fused heterocyclic ureas as highly potent TRPV1 antagonists

A series of N-[{2-(4-methylpiperidin-1-yl)-6-(trifluoromethyl)-pyridin-3-yl}methyl] N′-(6,6-fused heterocyclic) ureas have been investigated as hTRPV1 antagonists. Among them, compound 15 showed highly potent TRPV1 antagonism to capsaicin, with Ki(ant) = 0.2 nM, as well as antagonism to other activators, and it was efficacious in a pain model. A docking study of 15 with our hTRPV1 homology model indicates that there is crucial hydrogen bonding between the ring nitrogen and the receptor, contributing to its potency.

Substituted Bicyclic Aromatic Carboxamide and Urea Compounds as Vanilloid Receptor Ligands

Substituted bicyclic aromatic carboxamide and urea compounds as vanilloid receptor ligands, pharmaceutical compositions containing these compounds, and a method of using these compounds in the treatment and/or inhibition of pain and further diseases and/or disorders mediated at least in part via the vanilloid receptor 1 (VR1/TRPV1).