1421763-13-4

Basic information

• Product Name: cyclohexyl carbamo(dithioperoxo)imidate hydrochloride
• Synonyms: cyclohexyl carbamo(dithioperoxo)imidate hydrochloride
• CAS NO: 1421763-13-4
• Molecular Weight: 226.794
• Mol File: 1421763-13-4.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: cyclohexyl carbamo(dithioperoxo)imidate hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: cyclohexyl carbamo(dithioperoxo)imidate hydrochloride(1421763-13-4)
• EPA Substance Registry System: cyclohexyl carbamo(dithioperoxo)imidate hydrochloride(1421763-13-4)

Safety Data

• Hazardous Substances Data: 1421763-13-4(Hazardous Substances Data)

Upstream product

• 1569-69-3 Cyclohexanethiol 
• 17356-08-0 thiourea 

Downstream Products

• 28084-58-4 2-(cyclohexyldisulfanyl)benzo[d]thiazole 
• 40952-49-6 2-(cyclohexyldisulfanyl)-1H-benzo[d]imidazole 
• 51806-74-7 2-(cyclohexyldisulfanyl)benzo[d]oxazole 
• 1421763-04-3 6-Chloro-2-(cyclohexyldisulfanyl)-5-fluoro-1H-benzo[d]imidazole 
• 1421763-05-4 2-(Cyclohexyldisulfanyl)-5-nitro-1H-benzo[d]imidazole 
• 1421763-06-5 2-(Cyclohexyldisulfanyl)-5-ethoxy-1H-benzo[d]imidazole 
• 1421763-07-6 (2-(Cyclohexyldisulfanyl)-1H-benzo[d]imidazol-6-yl)(phenyl)-methanone 
• 1421763-08-7 2-Amino-8-(cyclohexyldisulfanyl)-7H-purin-6-ol 
• 1421763-09-8 8-(Cyclohexyldisulfanyl)-7H-purin-6-amine 
• 1421763-10-1 2-(Cyclohexyldisulfanyl)-4H-benzo[d][1,3]thiazine 
• 1421763-11-2 2-(Cyclohexyldisulfanyl)-5-phenyl-1H-imidazole 
• 1421763-12-3 3-(Cyclohexyldisulfanyl)-5-phenyl-4H-1,2,4-triazol-4-amine 

Relevant articles and documents

Selective inhibition of extracellular thioredoxin by asymmetric disulfides

Whereas the role of mammalian thioredoxin (Trx) as an intracellular protein cofactor is widely appreciated, its function in the extracellular environment is not well-understood. Only few extracellular targets of Trx-mediated thiol-disulfide exchange are known. For example, Trx activates extracellular transglutaminase 2 (TG2) via reduction of an intramolecular disulfide bond. Because hyperactive TG2 is thought to play a role in various diseases, understanding the biological role of extracellular Trx may provide critical insight into the pathogenesis of these disorders. Starting from a clinical-stage asymmetric disulfide lead, we have identified analogs with >100-fold specificity for Trx. Structure-activity relationship and computational docking model analyses have provided insights into the features important for enhancing potency and specificity. The most active compound identified had an IC 50 below 0.1 μM in cell culture and may be appropriate for in vivo use to interrogate the role of extracellular Trx in health and disease.