142217-77-4 Usage
General Description
The chemical (1S,2S,3S,5S)-5-(2-Amino-6-(benzyloxy)-9H-purin-9-yl)-3-(benzyloxy)-2-(benzyloxymethyl)cyclopentanol is a complex compound with a purine base and multiple benzyl group attachments. It is a cyclopentanol derivative with a purine moiety incorporating an amino group and multiple benzyloxy groups. The presence of these functional groups indicates that the compound may have potential biological activity, possibly interacting with purine receptors or enzymes involved in purine metabolism. The multiple benzyl group attachments also suggest that this compound may have some degree of lipophilicity, potentially affecting its pharmacokinetics and tissue distribution. Further research and investigation are needed to fully understand the chemical and biological properties of this complex molecule.
Check Digit Verification of cas no
The CAS Registry Mumber 142217-77-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,4,2,2,1 and 7 respectively; the second part has 2 digits, 7 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 142217-77:
(8*1)+(7*4)+(6*2)+(5*2)+(4*1)+(3*7)+(2*7)+(1*7)=104
104 % 10 = 4
So 142217-77-4 is a valid CAS Registry Number.
InChI:InChI=1/C32H33N5O4/c33-32-35-30-28(31(36-32)41-19-24-14-8-3-9-15-24)34-21-37(30)26-16-27(40-18-23-12-6-2-7-13-23)25(29(26)38)20-39-17-22-10-4-1-5-11-22/h1-15,21,25-27,29,38H,16-20H2,(H2,33,35,36)/t25-,26+,27+,29+/m1/s1
142217-77-4Relevant articles and documents
Method for synthesizing Entecavir intermediate
-
Paragraph 0031-0034, (2020/03/05)
The invention relates to a method for synthesizing an Entecavir intermediate and particularly relates to a method for synthesizing a compound represented by a formula I. According to the method, firstly, amino of 6-benzyloxy guanine is protected, and thus
BMS-200475, a novel carbocyclic 2'-deoxyguanosine analog with potent and selective anti-hepatitis B virus activity in vitro
Bisacchi,Chao,Bachard,Daris,Innaimo,Jacobs,Kocy,Lapointe,Martel,Merchant,Slusarchyk,Sundeen,Young,Colonno,Zahler
, p. 127 - 132 (2007/10/03)
BMS-200475, a never carbocyclic analog of 2'-deoxyguanosine, is a potent inhibitor of hepatitis B virus in vitro (ED50 = 3 nM) with relatively low cytotoxicity (CC50 = 21-120 μM). A practical 10-step asymmetric synthesis was developed affording BMS-200475 in 18% overall chemical yield and > 99% optical purity. The enantiomer of BMS-200475 as well as the adenine, thymine, and iodouracil analogs are much less active.