1422432-17-4

Basic information

• Product Name: C₁₁H₁₃NO₄S
• Synonyms: C₁₁H₁₃NO₄S
• CAS NO: 1422432-17-4
• Molecular Weight: 255.295
• Mol File: 1422432-17-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₁₁H₁₃NO₄S(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₁H₁₃NO₄S(1422432-17-4)
• EPA Substance Registry System: C₁₁H₁₃NO₄S(1422432-17-4)

Safety Data

• Hazardous Substances Data: 1422432-17-4(Hazardous Substances Data)

Upstream product

• 1422432-13-0 C₁₁H₁₃NO₃S 
• 103853-77-6 2-hydroxy-2-methyl-N-benzylpropanamide 

Relevant articles and documents

Synthesis and anticonvulsant activity of bioisosteres of trimethadione, N-derivative-1,2,3-oxathiazolidine-4-one-2,2-dioxides from α-hydroxyamides

The synthesis and anticonvulsant activity of novel heterocycles N-derivative-1,2,3-oxathiazolidine-4-one-2,2-dioxides, bioisosteres of trimethadione (TMD, oxazolidine-2,4-dione) and phenytoin (PHE), are described. TMD is an anticonvulsant drug widely used against absences seizures in the early 80's and PHE is an antiepileptic drug with a wide spectrum activity. The intermediates of synthesis of N-derivative-1,2,3-oxathiazolidine-4-one-2,2- dioxides, α-hydroxyamides, were obtained using microwave assisted synthesis. Anticonvulsant screening was performed in mice after intraperitoneal administration in the maximal electroshock seizure test (MES) and subcutaneous pentylenetetrazole seizures test (scPTZ). These new compounds showed a wide spectrum activity and were no neurotoxic in the RotoRod test. α-Hydroxyamides and N-derivative-1,2,3-oxathiazolidine-4-one-2,2-dioxides were 3-4700 times more potent than valproic acid in the MES test. Quantification of anticonvulsant protection was calculated (ED50) for the most active candidates; α-hydroxyamides 3a-c and 3e, and N-derivative- oxathiazolidine-4-one-2,2-dioxides 5a-c with ED50 values of 9.1, 53.9, 44.6, 25.2, 15.1, 91.1 and 0.06 mg/kg, respectively, in the MES test.