1422447-34-4

Basic information

• Product Name: 5-methoxy-2-(phenyl(p-toluenesulfonyl)methyl)phenol
• Synonyms: 5-methoxy-2-(phenyl(p-toluenesulfonyl)methyl)phenol
• CAS NO: 1422447-34-4
• Molecular Weight: 368.453
• Mol File: 1422447-34-4.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: 5-methoxy-2-(phenyl(p-toluenesulfonyl)methyl)phenol(CAS DataBase Reference)
• NIST Chemistry Reference: 5-methoxy-2-(phenyl(p-toluenesulfonyl)methyl)phenol(1422447-34-4)
• EPA Substance Registry System: 5-methoxy-2-(phenyl(p-toluenesulfonyl)methyl)phenol(1422447-34-4)

Safety Data

• Hazardous Substances Data: 1422447-34-4(Hazardous Substances Data)

Upstream product

• 13139-86-1 4-methoxyphenyl magnesium bromide 
• 926236-29-5 2-hydroxy-4-methoxybenzhydrol 
• 657-84-1 sodium tosylate 
• 100-58-3 phenylmagnesium bromide 
• 673-22-3 2-Hydroxy-4-methoxybenzaldehyde 
• 824-79-3 sodium 4-methylbenzenesulfinate 

Relevant articles and documents

Regio- A nd Enantioselective Friedel-Crafts Benzhydrylation of Indoles in Carbocyclic Ring with ortho-Quinomethanes: Access to Chiral Diarylindolylmethanes

The functionalization of indoles in the carbocyclic ring has been achieved via organocatalytic enantioselective Friedel-Crafts benzhydrylation of hydroxyindoles with in situ generated ortho-quinomethanes in oil-water biphases, allowing an efficient access to varied diarylindolylmethanes with a wide substrate scope. The high yields, excellent stereoselectivities, mild conditions, low catalyst loading, and easy scalability also demonstrated the interest of this novel methodology.

Bifunctional squaramide-catalyzed synthesis of chiral dihydrocoumarins via ortho-quinone methides generated from 2-(1-tosylalkyl)phenols

A bifunctional squaramide-catalyzed reaction of azlactones with o-quinone methides in situ generated from 2-(1-tosylalkyl)-phenols has been successfully developed under basic conditions, providing an efficient and mild access to chiral dihydrocoumarins bearing adjacent tertiary and quaternary stereogenic centers in high yields with excellent diastereo- and enantioselectivities.

Regioselective α-Addition of Deconjugated Butenolides: Enantioselective Synthesis of Dihydrocoumarins

The enantioselective α-addition of deconjugated butenolides has rarely been exploited, in contrast to the well-studied γ-addition of deconjugated butenolides. In this study, an unprecedented asymmetric α-addition/transesterification of deconjugated butenolides with ortho-quinone methides generated in situ afforded a series of functionalized 3,4-dihydrocoumarins containing two contiguous stereogenic centers with excellent diastereo- and enantioselectivity. DFT calculations suggested that the rarely observed regioselectivity was due to the distortion energy that resulted from the interaction between the nucleophilic dienolate and the electrophilic ortho-quinone methide.