142253-58-5

Basic information

• Product Name: 1-Boc-3-(cyanomethyl)azetidine
• Synonyms: 1-Boc-3-(cyanomethyl)azetidine;1-Azetidinecarboxylic acid, 3-(cyanomethyl)-, 1,1-dimethylethyl ester;3-(Cyanomethyl)-1-azetidinecarboxylic acid tert-butyl ester;tert-butyl 3-(cyanomethyl)azetidine-1-carboxylate
• CAS NO: 142253-58-5
• Molecular Formula: C10H16N2O2
• Molecular Weight: 196.25
• Mol File: 142253-58-5.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 310.1 °C at 760 mmHg
• Flash Point: 141.3 °C
• Appearance: /
• Density: 1.089
• Vapor Pressure: 0.000613mmHg at 25°C
• Refractive Index: 1.482
• Storage Temp.: 2-8°C
• PKA: -2.33±0.40(Predicted)
• CAS DataBase Reference: 1-Boc-3-(cyanomethyl)azetidine(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Boc-3-(cyanomethyl)azetidine(142253-58-5)
• EPA Substance Registry System: 1-Boc-3-(cyanomethyl)azetidine(142253-58-5)

Safety Data

• Hazardous Substances Data: 142253-58-5(Hazardous Substances Data)

Usage

General Description

1-Boc-3-(cyanomethyl)azetidine is a chemical compound with the formula C10H17N3O2 and a molecular weight of 207.26 g/mol. It is known for its use in the synthesis of pharmaceuticals and agrochemicals. The compound features a 1-butoxycarbonyl (Boc) protecting group, as well as a cyanomethyl group attached to a nitrogen-containing azetidine ring. These functional groups make it useful as a building block in organic synthesis, particularly in the preparation of heterocyclic compounds. Additionally, 1-Boc-3-(cyanomethyl)azetidine has been studied for its potential as an intermediate in the synthesis of bioactive compounds and has applications in the development of new materials and drug discovery.

InChI:InChI=1/C10H16N2O2/c1-10(2,3)14-9(13)12-6-8(7-12)4-5-11/h8H,4,6-7H2,1-3H3

Upstream product

• 557-21-1 zinc(II) cyanide 
• 1153949-11-1 3-(cyanomethylene)azetidine-1-carboxylic acid tert-butyl ester 
• 398489-26-4 tert-butyl 3-oxoazetidine-1-carboxylate 
• 142253-57-4 3-methanesulfonyloxymethyl-azetidine-1-carboxylic acid tert-butyl ester 
• 142253-56-3 3-hydroxymethyl-azetidine-1-carboxylic acid tert-butyl ester 

Relevant articles and documents

SUBSTITUTED 1H-IMIDAZO[1, 2-B]PYRAZOLE-3-CARBOXAMIDE AS BRUTON TYROSINE KINASE INHIBITORS

This invention relates to a series of compounds 1H-imidazo [1, 2-b] pyrazole-3-carboxamide substituted represented by formula I used as kinase inhibitors, in particular BTK inhibitors (Bruton tyrosine kinase), and the methods of manufacture and use thereof for the treatment of an autoimmune disease, inflammatory disease, cancer and potentially allergies.

Nickel-Catalyzed Deaminative Cyanation: Nitriles and One-Carbon Homologation from Alkyl Amines

A nickel-catalyzed deaminative cyanation of Katritzky pyridinium salts has been developed. When it is coupled with formation of the pyridinium salt from primary amines, this method enables alkyl amines to be converted to alkyl nitriles. A less toxic cyanide reagent, Zn(CN)2, is utilized, and diverse functional groups and heterocycles are tolerated. The method also enables a one-carbon homologation of alkyl amines via reduction of the nitrile products, in addition to many other potential transformations of the versatile nitrile group.

INDOLO SUBSTITUTED PIPERIDINE COMPOUND AS ESTROGEN RECEPTOR DEGRADING AGENT

Disclosed in the present invention is a type of indole substituted piperidine compounds as an estrogen receptor degrading agent. Specifically disclosed are a compound as shown in formula (I), a pharmaceutically acceptable salt, hydrate or prodrug thereof, a preparation method therefor, a pharmaceutical composition thereof, and a use thereof as an estrogen receptor degrading agent in the treatment of estrogen receptor positive breast cancers.