1422539-18-1

Basic information

• Product Name: 4-(2-nitrophenoxy)phenol
• Synonyms: 4-(2-nitrophenoxy)phenol
• CAS NO: 1422539-18-1
• Molecular Weight: 338.158
• Mol File: 1422539-18-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4-(2-nitrophenoxy)phenol(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(2-nitrophenoxy)phenol(1422539-18-1)
• EPA Substance Registry System: 4-(2-nitrophenoxy)phenol(1422539-18-1)

Safety Data

• Hazardous Substances Data: 1422539-18-1(Hazardous Substances Data)

Upstream product

• 150-76-5 4-methoxy-phenol 
• 6337-24-2 1-methoxy-4-(4-nitrophenoxy)benzene 
• 100-00-5 4-chlorobenzonitrile 

Downstream Products

• 1422539-05-6 C₂₉H₃₁N₃O₇ 
• 1422539-09-0 C₂₄H₂₃N₃O₅*ClH 

Relevant articles and documents

Optimization of 5-hydroxytryptamines as dual function inhibitors targeting phospholipase A2 and leukotriene A4 hydrolase

Dual function inhibitors targeting phospholipase A2 (PLA 2) and leukotriene A4 hydrolase (LTA4H) may balance the arachidonic acid (AA) metabolic network and be used as new anti-inflammatory drugs. In previous study, we discovered multi-target drugs towards the AA metabolic network, among which a dual-target inhibitor (JMC08-4) for human nonpancreatic secretory phospholipase A2 (hnps-PLA 2) and human leukotriene A4 hydrolase (LTA4H-h) was found. Based on the structure of compound JMC08-4, new dual-target inhibitors were designed assisted by molecular docking. In this report, a series of 5-hydroxytryptamine compounds were synthesized; and most of these title compounds showed more potent inhibitory activity than compound JMC08-4 in the in vitro bioassay against these two enzymes. The best one inhibited hnps-PLA 2 and LTA4H-h with IC50 values of 9.2 ± 0.5 μM and 2.4 ± 1.4 μM, respectively.