14226-97-2

Basic information

• Product Name: 3-OXO-5-CARBOXYPERHYDRO-1,4-THIAZINE
• Synonyms: 3-OXO-5-CARBOXYPERHYDRO-1,4-THIAZINE;5-OXO-THIOMORPHOLINE-3-CARBOXYLIC ACID;Carbocysteine impurity A
• CAS NO: 14226-97-2
• Molecular Formula: C5H7NO3S
• Molecular Weight: 161.18
• Product Categories: pharmacetical
• Mol File: 14226-97-2.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• Storage Temp.: Refrigerator
• Solubility: DMSO (Slightly), Methanol (Slightly)
• CAS DataBase Reference: 3-OXO-5-CARBOXYPERHYDRO-1,4-THIAZINE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-OXO-5-CARBOXYPERHYDRO-1,4-THIAZINE(14226-97-2)
• EPA Substance Registry System: 3-OXO-5-CARBOXYPERHYDRO-1,4-THIAZINE(14226-97-2)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 14226-97-2(Hazardous Substances Data)

Usage

Description

3-OXO-5-CARBOXYPERHYDRO-1,4-THIAZINE is a chemical compound that serves as an impurity in the pharmaceutical industry. It is specifically associated with Carbocistene (C178760), a mucolytic agent used for the treatment of various respiratory disorders.

Uses

Used in Pharmaceutical Industry:
3-OXO-5-CARBOXYPERHYDRO-1,4-THIAZINE is used as an impurity in the production of Carbocistene (C178760) for the treatment of respiratory disorders. The application reason is that it is a byproduct in the synthesis of Carbocistene, which is a mucolytic agent effective in managing conditions such as influenza virus infection and chronic obstructive pulmonary disease (COPD).

Upstream product

• 638-23-3 carbocisteine 
• 52-90-4 L-Cysteine 
• 921-01-7 rac-cysteine 
• 105-39-5 chloroacetic acid ethyl ester 
• 144-48-9 iodacetamide 
• 7048-04-6 L-cysteine hydrochloride monohydrate 

Downstream Products

• 1214789-18-0 C₁₂H₁₃NO₃S 
• 65057-42-3 Otc-His-Pro-NHPhEt 

Relevant articles and documents

A chloroacetate based ratiometric fluorescent probe for cysteine detection in biosystems

The specific detection of cysteine (Cys) over homocysteine (Hcy), glutathione (GSH) and other amino acids is of great significance for studying its biological functions as well as for the diagnosis of related diseases. Chloroacetyl group was often used as a reaction site for cysteine fluorescent probes for its sensitivity and selectivity. However, high background fluorescence and low stability are common problems encountered by such probes. Here, four chloroacetyl group based fluorescent probes (C1, C2, C3, and H4) was synthesized for a comparative study. We found that the inefficient quenching ability of chloroacetyl group turned into an advantage when connected with a ratiometric fluorophore. With the modification of chloroacetyl group, probe H4 displayed excellent ratiometric property and great selectivity for Cys, the stability was also improved. Additionally, the probe was successfully applied for quantitative detection of Cys in fetal bovine serum and real-time imaging in living HeLa cells with low toxicity.

Syntheses of metabolites of S-carbxymethyl-L-cysteine and S-methyl-L-cysteine and of some isotopically labelled (2H,13C) analogues

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Peptides

A novel peptide of the formula: STR1 wherein A is hydrogen, alkyl, aralkyl, alkoxyalkyl, hydroxyalkyl or alkoxy; R is STR2 X is --S-- or --(CH2)n -- where n is 1 or 2 has a weaker TRH releasing activity than TRH and a stronger anaesthesia-antagonistic activity, spontaneous movement-stimulant activity or dopamine-potentiating activity than TRH.