1422970-29-3

Basic information

• Product Name: tert-butyl ((2S,3R)-3-(tert-butoxy)-1-oxo-1-(2-(3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)hydrazinyl)butan-2-yl)carbamate
• CAS NO: 1422970-29-3
• Molecular Weight: 491.436
• Mol File: 1422970-29-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: tert-butyl ((2S,3R)-3-(tert-butoxy)-1-oxo-1-(2-(3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)hydrazinyl)butan-2-yl)carbamate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-butyl ((2S,3R)-3-(tert-butoxy)-1-oxo-1-(2-(3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)hydrazinyl)butan-2-yl)carbamate(1422970-29-3)
• EPA Substance Registry System: tert-butyl ((2S,3R)-3-(tert-butoxy)-1-oxo-1-(2-(3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)hydrazinyl)butan-2-yl)carbamate(1422970-29-3)

Safety Data

• Hazardous Substances Data: 1422970-29-3(Hazardous Substances Data)

Upstream product

• 27246-81-7 3-bromophenylhydrazine hydrochloride 
• 13734-40-2 (2S,3R)-3-tert-butoxy-2-tert-butoxycarbonylaminobutyric acid 
• 1422970-08-8 tert-butyl ((2S,3R)-1-(2-(3-bromophenyl)hydrazinyl)-3-(tertbutoxy)-1-oxobutan-2-yl)carbamate 
• 73183-34-3 bis(pinacol)diborane 

Downstream Products

• 1422970-09-9 C₁₈H₁₉ClN₆O₂ 
• 1432439-25-2 C₂₇H₃₆ClN₅O₅S 

Relevant articles and documents

Identification of bacteria-selective threonyl-tRNA synthetase substrate inhibitors by structure-based design

A series of potent and bacteria-selective threonyl-tRNA synthetase (ThrRS) inhibitors have been identified using structure-based drug design. These compounds occupied the substrate binding site of ThrRS and showed excellent binding affinities for all of the bacterial orthologues tested. Some of the compounds displayed greatly improved bacterial selectivity. Key residues responsible for potency and bacteria/human ThrRS selectivity have been identified. Antimicrobial activity has been achieved against wild-type Haemophilus influenzae and efflux-deficient mutants of Escherichia coli and Burkholderia thailandensis.