1423-27-4 Usage
Description
2-Trifluoromethylphenylboronic acid is a white to light beige crystalline powder that serves as a versatile reagent in various chemical reactions and pharmaceutical applications. It is characterized by its trifluoromethyl group attached to a phenylboronic acid structure, which provides unique properties and reactivity in chemical synthesis.
Uses
Used in Pharmaceutical Industry:
2-Trifluoromethylphenylboronic acid is used as a reagent for the preparation of potent inhibitors of human uric acid transporter 1 (hURAT1). These inhibitors play a crucial role in the treatment of hyperuricemia and gout by regulating uric acid levels in the body.
Used in Chemical Synthesis:
2-Trifluoromethylphenylboronic acid is used as a reactant in Suzuki-coupling reactions to prepare 2-trifluoromethyl aryl or heteroaryl derivatives. These derivatives are valuable building blocks in the synthesis of various pharmaceuticals and agrochemicals.
Used in the Synthesis of Antagonists:
2-(Trifluoromethyl)phenylboronic acid can be used to synthesize 4-(2-trifluoromethyl)phenylpyrrolo[2,3-d]pyrimidine, which is a potential antagonist of corticotropin-releasing hormone. This antagonist has potential applications in the treatment of stress-related disorders and other conditions influenced by the corticotropin-releasing hormone system.
Used in Nitration Reactions:
2-Trifluoromethylphenylboronic acid is used to prepare 2-nitro-6-(trifluoromethyl)phenylboronic acid through nitration reactions. 2-Trifluoromethylphenylboronic acid can be further utilized in the synthesis of various organic compounds and pharmaceuticals.
Check Digit Verification of cas no
The CAS Registry Mumber 1423-27-4 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 1,4,2 and 3 respectively; the second part has 2 digits, 2 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 1423-27:
(6*1)+(5*4)+(4*2)+(3*3)+(2*2)+(1*7)=54
54 % 10 = 4
So 1423-27-4 is a valid CAS Registry Number.
InChI:InChI=1/3C5H2F6O2.Bi.6H/c3*6-4(7,8)2(12)1-3(13)5(9,10)11;;;;;;;/h3*1,12H;;;;;;;/q;;;+3;;;;;;/p-3/b3*2-1-;;;;;;;/r3C5H2F6O2.BiH6/c3*6-4(7,8)2(12)1-3(13)5(9,10)11;/h3*1,12H;1H6/q;;;+3/p-3/b3*2-1-;
1423-27-4Relevant articles and documents
Low-valent niobium-mediated double activation of C-F/C-H bonds: Fluorene synthesis from o-arylated α,α,α-trifluorotoluene derivatives
Fuchibe, Kohei,Akiyama, Takahiko
, p. 1434 - 1435 (2006)
By the treatment of 0.3 molar amount of NbCl5 and LiAlH4, o-arylated α,α,α-trifluorotoluenes afforded fluorene derivatives in good yields. C-F bonds of the CF3 group and the neighboring ortho C-H bond were doubly activated to give the coupling products. Copyright
Synthesis and evaluation of sulfonamide derivatives as potent Human Uric Acid Transporter 1 (hURAT1) inhibitors
Yang, Xintuo,Pang, Xuehai,Fan, Lei,Li, Xinghai,Chen, Yuanwei
supporting information, p. 1919 - 1922 (2017/04/10)
This letter presents synthesis and structure-activity relationship study of sulfonamide derivatives as inhibitors of Human Uric Acid Transporter 1 (hURAT1). Among all tested sulfonamide derivatives, compounds 9b, 16i and 19b exhibited excellent inhibition activity with IC50 value of 10, 2, and 83?nM, respectively. In addition, compounds 9b and 19b demonstrated moderate PK profile in rats.
OXYGEN OR SULFUR CONTAINING 5-MEMBERED HETEROAROMATICS AS FACTOR Xa INHIBITORS
-
, (2008/06/13)
The present application describes oxygen and sulfur containing heteroaromatics and derivatives thereof of formula (I), or pharmaceutically acceptable salt or prodrug forms thereof, wherein J is O or S and D may be C(=NH)NH2, which are useful as inhibitors of factor Xa.
