1424-52-8

Basic information

• Product Name: Benzenesulfonyl isothiocyanate, 4-methyl-
• CAS NO: 1424-52-8
• Molecular Formula: C8H7NO2S2
• Molecular Weight: 213.281
• Mol File: 1424-52-8.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: Benzenesulfonyl isothiocyanate, 4-methyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenesulfonyl isothiocyanate, 4-methyl-(1424-52-8)
• EPA Substance Registry System: Benzenesulfonyl isothiocyanate, 4-methyl-(1424-52-8)

Safety Data

• Hazardous Substances Data: 1424-52-8(Hazardous Substances Data)

Upstream product

• 333-20-0 potassium thioacyanate 
• 98-59-9 p-toluenesulfonyl chloride 
• 70-55-3 toluene-4-sulfonamide 
• 75-15-0 carbon disulfide 
• 75-44-5 phosgene 
• 5706-65-0 dipotassium p-tolylsulfonyl dithiocarbamate 

Downstream Products

• 111385-72-9 bis-(piperidine-1-thiocarbonyl)-(toluene-4-sulfonyl)-amine 
• 23889-46-5 2-(1-methylamino-ethylidene)-N-(toluene-4-sulfonyl)-3-thio-malonamic acid ethyl ester 
• 23889-47-6 2-(1-ethylamino-ethylidene)-N-(toluene-4-sulfonyl)-3-thio-malonamic acid ethyl ester 
• 23889-48-7 2-(1-anilino-ethylidene)-N-(toluene-4-sulfonyl)-3-thio-malonamic acid ethyl ester 
• 36791-69-2 N-(3-phenyl-4-phenylimino-[1,3]thiazetidin-2-ylidene)-toluene-4-sulfonamide 
• 54999-96-1 4-benzyl-5-benzylimino-3-tosylimino-1,2,4-dithiazolidine 
• 133150-02-4 N-[1,7-Dibenzyl-6-oxo-6,7-dihydro-1H-4λ⁴-[1,2,4]dithiazolo[1,5-b][1,2,4]dithiazol-(2Z)-ylidene]-4-methyl-benzenesulfonamide 
• 75483-24-8 N-[Bis-(2-hydroxy-1,1-dimethyl-ethylamino)-mercapto-methyl]-4-methyl-benzenesulfonamide 
• 77903-99-2 N-[4-Ethoxy-thietan-(2E)-ylidene]-4-methyl-benzenesulfonamide 
• 75499-05-7 N-(4-toluenesulfonyl)-N¹-(1-(3-hydroxypropyl))thiourea 
• 39672-12-3 4-Methyl-N-[2-(N'-methyl-N'-phenyl-hydrazino)-cyclopent-1-enecarbothioyl]-benzenesulfonamide 
• 39672-11-2 N-[2-(N',N'-Dimethyl-hydrazino)-cyclopent-1-enecarbothioyl]-4-methyl-benzenesulfonamide 
• 39672-10-1 4-Methyl-N-[2-(1-phenyl-ethylamino)-cyclohex-1-enecarbothioyl]-benzenesulfonamide 
• 39672-13-4 N-[2-(N',N'-Diphenyl-hydrazino)-cyclopent-1-enecarbothioyl]-4-methyl-benzenesulfonamide 

Relevant articles and documents

Na2S2O8-mediated efficient synthesis of isothiocyanates from primary amines in water

We have developed two green, practical, and efficient procedures, including a one-pot one, to synthesize isothiocyanates from amines and carbon disulfide via desulfurization with sodium persulfate. Water is used as the solvent. Basic conditions are necessary for good chemoselectivity for isothiocyanates. Structurally diverse linear and branched alkyl amines and aryl amines are readily converted to isothiocyanates by the two procedures in satisfactory yields. Halogens, benzylic C-H bonds, methylthio, nitro, ester, alkenyl, electron-rich or -deficient (hetero)aryls, acetylenyl, and even phenolic and alcoholic hydroxyls are well tolerated. The one-pot procedure in water can also be used to realize the preparation of chiral isothiocyanates from chiral amines, and the modification of bioactive structures with free amino groups. In large-scale preparation, simple and practical purification procedures independent of column chromatography are developed.

The invention of radical reactions. Part XXXV. A novel radical fission reaction of N-sulfonylthioxocarbamates

A novel radical fission reaction of N-sulfonylthioxocarbamates, obtained from the reaction of alcohols with methanesulfonyl- and toluenesulfonyl isothiocyanates, to give the corresponding O-alkylthioxocarbamates, is described.