142533-52-6

Basic information

• Product Name: Ethanone, 2-bromo-1-phenyl-, O-methyloxime, (Z)-
• CAS NO: 142533-52-6
• Molecular Formula: C9H10BrNO
• Molecular Weight: 228.088
• Mol File: 142533-52-6.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: Ethanone, 2-bromo-1-phenyl-, O-methyloxime, (Z)-(CAS DataBase Reference)
• NIST Chemistry Reference: Ethanone, 2-bromo-1-phenyl-, O-methyloxime, (Z)-(142533-52-6)
• EPA Substance Registry System: Ethanone, 2-bromo-1-phenyl-, O-methyloxime, (Z)-(142533-52-6)

Safety Data

• Hazardous Substances Data: 142533-52-6(Hazardous Substances Data)

Upstream product

• 593-56-6 N-methoxylamine hydrochloride 
• 70-11-1 α-bromoacetophenone 

Downstream Products

• 1356599-86-4 (4-{[(2Z)-2-(methoxyimino)-2-phenylethyl]oxy}phenyl)methanol 
• 1356599-82-0 4-{[(2Z)-2-(methoxyimino)-2-phenylethyl]oxy}benzaldehyde 
• 1356600-17-3 3-fluoro-4-{[(2E,2Z)-2-(methoxyimino)-2-phenylethyl]oxy}benzaldehyde 
• 1356600-16-2 methyl 3-{4-[(4-{[(2Z)-2-(methoxyimino)-2-phenylethyl]oxy}benzyl)oxy]phenyl}-3-(1,2-oxazol-3-yl)propanoate 
• 1356598-73-6 3-{4-[(4-{[(2Z)-2-(methoxyimino)-2-phenylethyl]oxy}benzyl)oxy]phenyl}-3-(1,2-oxazol-3-yl)propanoic acid 
• 1356600-18-4 (1E,1Z)-2-[2-fluoro-4-(hydroxymethyl)phenoxy]-1-phenylethanone O-methyloxime 
• 1356600-19-5 (1E,1Z)-2-[4-(bromomethyl)-2-fluorophenoxy]-1-phenylethanone O-methyloxime 
• 1356600-21-9 methyl 3-cyano-3-{4-[(3-fluoro-4-{[(2E,2Z)-2-(methoxyimino)-2-phenylethyl]oxy}benzyl)oxy]phenyl}propanoate 
• 1356598-77-0 3-cyano-3-{4-[(3-fluoro-4-{[(2E,2Z)-2-(methoxyimino)-2-phenylethyl]oxy}benzyl)oxy]phenyl}propanoic acid 
• 1356600-22-0 4-[(4-{[(2E,2Z)-2-(methoxyimino)-2-phenylethyl]oxy}benzyl)oxy]benzaldehyde 
• 1356600-23-1 {4-[(4-{[(2E,2Z)-2-(methoxyimino)-2-phenylethyl]oxy}benzyl)oxy]phenyl}methanol 
• 1356598-86-1 ({4-[(4-{[(2E,2Z)-2-(methoxyimino)-2-phenylethyl]oxy}benzyl)oxy]benzyl}oxy)acetic acid 
• 1356600-26-4 2-(4-(bromomethyl)phenoxy)-1-phenylethanone O-methyl oxime 
• 1356600-27-5 ethyl 4-{4-[(4-{[(2E,2Z)-2-(methoxyimino)-2-phenylethyl]oxy}benzyl)oxy]phenyl}-5-methyl-1,2-oxazole-3-carboxylate 

Relevant articles and documents

Palladium-catalyzed suzuki carbonylative reaction of a-halomethyl oxime ethers: A regioselective route to unsymmetrical 1,3-oxyiminoketones

The three-component reaction of a-halomethyl oxime ethers, boronic acids and carbon monoxide at atmospheric pressure catalyzed by tetrakis- (triphenylphosphine)palladium(0) gives efficiently unsymmetrical b-alkoxyimino carbonyl compounds with total control of the regioselectivity, in high yield and atomic economy. Simple commercially available starting materials are used in this synthetic procedure. The three components assembly takes place preferentially versus the competing direct coupling or other possible side reactions. The mechanism of the transformation was investigated by NMR and intermediate palladium(II) complexes were detected.

PROCESS FOR THE PREPARATION OF AN ARYL OXIME AND SALTS THEREOF

The invention relates to a process for the preparation of 3-cyano-3-{4-[(4-{[(2Z)-2-(methoxyimino)-2-phenylethyl] oxy} benzyl) oxy] phenyl} propanoic acid or salts thereof. In one form, the invention relates to the process for the preparation of (-)-3-cyano-3-{4-[(4-{[(2Z)-2-(methoxyimino)-2-phenylethyl]oxy}benzyl)oxy]phenyl}propanoic acid and conversion of the (-)-enantiomer to the sodium salt, sodium 3-cyano-3-{4-[(4-{[(2Z)-2-(methoxyimino)-2-phenylethyl]oxy}benzyl)oxy] phenyl}propanoate.